A Quantitative Method for Simultaneous Determination of 5-Methoxy-N,N-Diisopropyltryptamine and its Metabolites in Urine Using Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry
DC Field | Value | Language |
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dc.contributor.author | Jin, Ming J. | - |
dc.contributor.author | Jin, Changbae | - |
dc.contributor.author | Kim, Jin Y. | - |
dc.contributor.author | In, Moon K. | - |
dc.contributor.author | Kwon, Oh S. | - |
dc.contributor.author | Yoo, Hye H. | - |
dc.date.accessioned | 2021-06-23T10:40:38Z | - |
dc.date.available | 2021-06-23T10:40:38Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2011-07 | - |
dc.identifier.issn | 0022-1198 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/37324 | - |
dc.description.abstract | 5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a designer hallucinogen derived from tryptamine and is reportedly abused and involved in criminal activities. For the detection of 5-MeO-DIPT use, a liquid chromatography-tandem mass spectrometric method for 5-MeO-DIPT and its metabolites, 5-hydroxy-N,N-diisopropyltryptamine (5-OH-DIPT) and 5-methoxy-N,N-isopropyltryptamine (5-MeO-IPT) was developed and validated in rat urine. The urine samples were pretreated by protein precipitation with acetonitrile and introduced into a BDS HYPERSIL C-18 column (50 x 2.0 mm, 5 mu m) for chromatographic separation. Mobile phases consisted of methanol, water, and 1% formic acid, and gradient elution was used at a flow rate of 0.2 mL/min. For the MS detection, multiple-reaction monitoring analysis was adopted. The linear range was 0.01-10 mu g/mL, and the lower limit of quantification was 10 ng/mL for all analytes. The intra- and interday accuracies and precisions met the criteria (< 15%). The developed method was successfully applied to the drug-treated rat urine. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | American Society for Testing and Materials | - |
dc.title | A Quantitative Method for Simultaneous Determination of 5-Methoxy-N,N-Diisopropyltryptamine and its Metabolites in Urine Using Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Hye H. | - |
dc.identifier.doi | 10.1111/j.1556-4029.2011.01753.x | - |
dc.identifier.scopusid | 2-s2.0-79960060046 | - |
dc.identifier.wosid | 000292448400034 | - |
dc.identifier.bibliographicCitation | Journal of Forensic Sciences, v.56, no.4, pp.1044 - 1048 | - |
dc.relation.isPartOf | Journal of Forensic Sciences | - |
dc.citation.title | Journal of Forensic Sciences | - |
dc.citation.volume | 56 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1044 | - |
dc.citation.endPage | 1048 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Legal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Legal | - |
dc.subject.keywordPlus | LIVER-MICROSOMES | - |
dc.subject.keywordPlus | N,N-DIISOPROPYLTRYPTAMINE | - |
dc.subject.keywordPlus | FOXY | - |
dc.subject.keywordAuthor | forensic science | - |
dc.subject.keywordAuthor | 5-MeO-DIPT | - |
dc.subject.keywordAuthor | 5-OH-DIPT | - |
dc.subject.keywordAuthor | 5-MeO-IPT | - |
dc.subject.keywordAuthor | urine | - |
dc.subject.keywordAuthor | LC/MS/MS | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/j.1556-4029.2011.01753.x | - |
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