Synthesis of Radioiodinated Carbocyclic Cytosine Analogues
DC Field | Value | Language |
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dc.contributor.author | Ahn, Hyunseok | - |
dc.contributor.author | An, Gwangil | - |
dc.contributor.author | Rhee, Hakjune | - |
dc.date.accessioned | 2021-06-23T10:41:14Z | - |
dc.date.available | 2021-06-23T10:41:14Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2011-06 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/37358 | - |
dc.description.abstract | The synthesis of carbocyclic analogues of normal nucleosides has grown exclusively since they have shown potential antiviral and antitumor activities. Radiolabeled cis-1[4-(hydroxy-methyl)-cyclopent-2-enyl]-5-[I-124]-iodocytosine (carbocyclic d4IC) and cis-1[4-(hydroxy-methyl)-cyclopent-2-enyl]-5-(2-[I-124]iodovinyl)cytosine (carbocyclic d4IVC) were synthesized. The synthetic route employed Pd(0)-catalyzed coupling reaction together with organotin and exchange reaction for radioiodination as key reactions. Carbocyclic [I-124]d4IC gave more than 75% radiochemical yield with greater than 95% radiochemical purity. Carbocyclic [I-124]d4IVC gave more than 80% radiochemical yield with greater than 95% radiochemical purity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한화학회 | - |
dc.title | Synthesis of Radioiodinated Carbocyclic Cytosine Analogues | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rhee, Hakjune | - |
dc.identifier.doi | 10.5012/bkcs.2011.32.6.1931 | - |
dc.identifier.scopusid | 2-s2.0-79959463142 | - |
dc.identifier.wosid | 000292117700017 | - |
dc.identifier.bibliographicCitation | Bulletin of the Korean Chemical Society, v.32, no.6, pp.1931 - 1935 | - |
dc.relation.isPartOf | Bulletin of the Korean Chemical Society | - |
dc.citation.title | Bulletin of the Korean Chemical Society | - |
dc.citation.volume | 32 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1931 | - |
dc.citation.endPage | 1935 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001558880 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | THYMIDINE KINASE GENE | - |
dc.subject.keywordPlus | PET IMAGING AGENT | - |
dc.subject.keywordPlus | ANTIVIRAL ACTIVITY | - |
dc.subject.keywordPlus | FACILE SYNTHESIS | - |
dc.subject.keywordPlus | CELLULAR UPTAKE | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordPlus | NUCLEOSIDES | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordAuthor | Carbocyclic nucleoside | - |
dc.subject.keywordAuthor | Radioiodine | - |
dc.subject.keywordAuthor | PET | - |
dc.subject.keywordAuthor | Radiopharmaceutical | - |
dc.subject.keywordAuthor | Labeling | - |
dc.identifier.url | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001558880 | - |
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