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Facile synthesis and biological evaluation of 3,3-diphenylpropanoyl piperazines as T-type calcium channel blockers
- Authors
- Choi, Yeon-hee; Baek, Du Jong; Seo, Seon Hee; Lee, Jae Kyun; Pae, Ae Nim; Cho, Yong Seo; Min, Sun-Joon
- Issue Date
- Jan-2011
- Publisher
- Pergamon Press Ltd.
- Keywords
- T-Type calcium channel blockers; Meldrum's acid; 3,3-Diphenylpropanoyl piperazine; HTS assays
- Citation
- Bioorganic and Medicinal Chemistry Letters, v.21, no.1, pp 215 - 219
- Pages
- 5
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Bioorganic and Medicinal Chemistry Letters
- Volume
- 21
- Number
- 1
- Start Page
- 215
- End Page
- 219
- ISSN
- 0960-894X
1464-3405
- Abstract
- We have developed a facile synthesis of 3,3-diphenylpropanamides using Meldrum's acid derivatives as amide coupling components. The in vitro biological evaluation of the title compounds led to the identification of compound 1h, which has good inhibitory activity against T-type calcium channel (IC50 = 0.83 mu M). (C) 2010 Elsevier Ltd. All rights reserved.
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Related Researcher
- Min, Sun Joon
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY (DEPARTMENT OF CHEMICAL AND MOLECULAR ENGINEERING)