Identfication of phase I and phase II metabolites of hesperetin in rat liver microsomes by liquid chromatography-electrospray ionization-tandem mass spectrometry
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Unyong. | - |
dc.contributor.author | Han, Sang Beom | - |
dc.contributor.author | Kwon, Oh-Seung | - |
dc.contributor.author | Yoo, Hye Hyun | - |
dc.date.accessioned | 2021-06-23T12:04:09Z | - |
dc.date.available | 2021-06-23T12:04:09Z | - |
dc.date.created | 2021-01-22 | - |
dc.date.issued | 2011-03 | - |
dc.identifier.issn | 2233-4203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/39110 | - |
dc.description.abstract | The purpose of this study is to investigate the in vitro metabolism of hesperetin, a bioflavonoid. Hesperetin was incubated with rat liver microsomes in the presence of NADPH and UDP-glucuronic acid for 30 min. The reaction mixture was analyzed by liquid chromatography-ion trap mass spectrometer and the chemical structures of hesperetin metabolites were characterzed based on their MS/MS spectra. As a result, a total of five metabolites were detected in rat liver microsomes. The metabolites were identified as a demethylated metabolite (eriodictyol), two hesperetin glucuronides, and two eriodictyol glucuronides. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean Society for Mass Spectrometry | - |
dc.title | Identfication of phase I and phase II metabolites of hesperetin in rat liver microsomes by liquid chromatography-electrospray ionization-tandem mass spectrometry | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Hye Hyun | - |
dc.identifier.doi | 10.5478/MSL.2011.2.1.020 | - |
dc.identifier.scopusid | 2-s2.0-84878639722 | - |
dc.identifier.bibliographicCitation | Mass Spectrometry Letters, v.2, no.1, pp.20 - 23 | - |
dc.relation.isPartOf | Mass Spectrometry Letters | - |
dc.citation.title | Mass Spectrometry Letters | - |
dc.citation.volume | 2 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 20 | - |
dc.citation.endPage | 23 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001911679 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Hesperetin | - |
dc.subject.keywordAuthor | In vitro metabolism | - |
dc.subject.keywordAuthor | LC/MS | - |
dc.subject.keywordAuthor | Rat liver microsomes | - |
dc.identifier.url | http://koreascience.or.kr/article/JAKO201110441050401.page | - |
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