In situ growth of a thermoresponsive polymer from a genetically engineered elastin-like polypeptide
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gao, Weiping | - |
dc.contributor.author | Xu, Donghua | - |
dc.contributor.author | Lim, Dong Woo | - |
dc.contributor.author | Craig, Stephen L. | - |
dc.contributor.author | Chilkoti, Ashutosh | - |
dc.date.accessioned | 2021-06-23T12:06:24Z | - |
dc.date.available | 2021-06-23T12:06:24Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2011-07 | - |
dc.identifier.issn | 1759-9954 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/39198 | - |
dc.description.abstract | We report the in situ growth of a thermoresponsive dumbbell-like polymer conjugate of a genetically engineered triblock elastin-like polypeptide (tELP). Atom transfer radical polymerization (ATRP) was used to directly grow a PEG-like polymer selectively from the first and third blocks of the tELP to form a poly(oligo(ethylene glycol) methyl ether methacrylate) (poly(OEGMA)) brush conjugate with quantitative yield. We found that in situ growth of poly(OEGMA) from tELP significantly changed the inverse phase transition and rheological behaviors of tELP. Dynamic light scattering (DLS) and turbidity measurements as a function of temperature showed that the inverse phase transition behavior of the conjugate was not determined by the tELP but by poly(OEGMA). Oscillatory rheological measurements indicated that the conjugate started to form a physical hydrogel at a temperature of 55 degrees C. In vitro enzymatic degradation studies showed that the conjugate could be degraded by collagenase. These results suggest that this class of conjugates may be potentially useful as an injectable, thermoresponsive drug carrier for local drug delivery and as a scaffold for tissue engineering. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | In situ growth of a thermoresponsive polymer from a genetically engineered elastin-like polypeptide | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Dong Woo | - |
dc.identifier.doi | 10.1039/c1py00074h | - |
dc.identifier.scopusid | 2-s2.0-80855136341 | - |
dc.identifier.wosid | 000291613700020 | - |
dc.identifier.bibliographicCitation | POLYMER CHEMISTRY, v.2, no.7, pp.1561 - 1566 | - |
dc.relation.isPartOf | POLYMER CHEMISTRY | - |
dc.citation.title | POLYMER CHEMISTRY | - |
dc.citation.volume | 2 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1561 | - |
dc.citation.endPage | 1566 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | SMART POLYMERS | - |
dc.subject.keywordPlus | FUSION PROTEIN | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | TERMINUS | - |
dc.subject.keywordPlus | BRUSHES | - |
dc.identifier.url | https://pubs.rsc.org/en/content/articlelanding/2011/PY/c1py00074h | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.