Genomic comparison of insecticides and herbicide in human hepatoma (HepG2) cell line

Abstract

Pesticide is a chemical substance, biological agent, antimicrobial, disinfectant or device used against any pest, and it can be grouped in several different ways. Atrazine is one of the most commonly used herbicides found in the rural environments, permethrin and prallethrin are pyrethroid insecticides. In this study, we compared the characters of herbicide and insecticide by cytotoxicity and microarray experiments. In the cytotoxicity tests, we couldn't find specific chemical features. However, in the gene expression analysis, we found that insecticides affects to RNA processing and RNA metabolism, and especially, in the energy metabolism, such as generation of precursor metabolites and energy, and energy derivation by oxidation of organic compounds, herbicides and insecticides are differently working. This study provides characteristics of two pesticides by checking the transcriptional change.