Effect of zinc oxide on the rheological and mucoadhesive properties of poloxamer 407-based mucoadhesive thermosensitive gel
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Tae-Hwan | - |
dc.contributor.author | Kim, Sung Tae | - |
dc.contributor.author | Park, Jeong-Sook | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Kim, Hyung Tae | - |
dc.contributor.author | Kim, Chong-Kook | - |
dc.date.accessioned | 2021-06-23T12:08:14Z | - |
dc.date.available | 2021-06-23T12:08:14Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2010-12 | - |
dc.identifier.issn | 0363-9045 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/39286 | - |
dc.description.abstract | Background: To improve the therapeutic efficacy of drugs for hemorrhoid, mucoadhesive thermosensitive gel (MTG) system was developed. Methods: The MTG was prepared using poloxamer 407 (P407, 13% and 14%), polycarbophil (PC, 0.2% w/v), phenylephrine hydrochloride (0.25% w/v), lidocaine hydrochloride (1.88% w/v), and prednisolone acetate (0.05% w/v). Then, zinc oxide (ZnO) was added as an astringent as well as mucoadhesiveness-enhancing agent. Two kinds of poloxamer-based MTGs were compared in aspects of rheology, mucoadhesiveness, syringeability, and in vitro release study. Results: Both the two MTGs (13% and 14% P407) showed Newtonian behavior at 20 degrees C whereas pseudoplastic flow at 37 degrees C. The addition of ZnO into MTGs enhanced the mucoadhesiveness and syringeability and led the drug components to be released in accordance with Fickian mechanism. Conclusions: Taken together, the MTG-containing ZnO can be a more effective and convenient delivery system for the treatment of hemorrhoid with a reduced dosage interval. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Effect of zinc oxide on the rheological and mucoadhesive properties of poloxamer 407-based mucoadhesive thermosensitive gel | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.3109/03639045.2010.487266 | - |
dc.identifier.scopusid | 2-s2.0-78149374548 | - |
dc.identifier.wosid | 000283874400006 | - |
dc.identifier.bibliographicCitation | DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, v.36, no.12, pp.1436 - 1443 | - |
dc.relation.isPartOf | DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | - |
dc.citation.title | DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | - |
dc.citation.volume | 36 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1436 | - |
dc.citation.endPage | 1443 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | LIQUID SUPPOSITORY | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | BIOAVAILABILITY | - |
dc.subject.keywordPlus | HEMORRHOIDS | - |
dc.subject.keywordPlus | ADDITIVES | - |
dc.subject.keywordPlus | HYDROGELS | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | MUCOSAL | - |
dc.subject.keywordPlus | ZNO | - |
dc.subject.keywordAuthor | Hemorrhoid | - |
dc.subject.keywordAuthor | mucoadhesive | - |
dc.subject.keywordAuthor | poloxamer 407 | - |
dc.subject.keywordAuthor | thermosensitive gel | - |
dc.subject.keywordAuthor | zinc oxide | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.3109/03639045.2010.487266 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.