Synthesis and evaluation of stilbene derivatives as a potential imaging agent of amyloid plaques
DC Field | Value | Language |
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dc.contributor.author | Hong, Myeng Chan | - |
dc.contributor.author | Kim, Yun Kyung | - |
dc.contributor.author | Choi, Jae Yong | - |
dc.contributor.author | Yang, Si Qiang | - |
dc.contributor.author | Rhee, Hakjune | - |
dc.contributor.author | Ryu, Young Hoon | - |
dc.contributor.author | Choi, Tae Hyun | - |
dc.contributor.author | Cheon, Gi Jeong | - |
dc.contributor.author | Il An, Gwang | - |
dc.contributor.author | Kim, Hye Yun | - |
dc.contributor.author | Kim, Youngsoo | - |
dc.contributor.author | Kim, Dong Jin | - |
dc.contributor.author | Lee, Jun-Seok | - |
dc.contributor.author | Chang, Young-Tae | - |
dc.contributor.author | Lee, Kyo Chul | - |
dc.date.accessioned | 2021-06-23T12:37:57Z | - |
dc.date.available | 2021-06-23T12:37:57Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2010-11 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/39355 | - |
dc.description.abstract | Fluorescence probes that can detect A beta (beta-amyloid peptide) plaque are important tools for diagnosis of Alzheimer's disease (AD), and 4-N-methylamino-4'-hydroxystilbene (SB-13) is one of the promising candidate molecules. We report here the synthesis of SB-13 derivatives that consist of various electron donating/withdrawing moieties and distinct size of N-substituents. The synthesized compounds were screened for detection of A beta 40 fibrils in vitro. Four compounds exhibited more than sixfold intensity increase, and they were further analyzed for detail bindings and A beta plaque imaging. Among these molecules, compound 42 meets two critical requirements for imaging agent; high fluorescence responsiveness and strong binding affinity. This compound showed more than 25-fold increase with the dissociation constant of 1.13 +/- 0.37 mu M. In AD mouse brain tissue, 42 selectively stained A beta plaque, more specifically peripheral regions of A beta plaque. This finding demonstrated its potential use as brain-imaging agents for AD studies. (C) 2010 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.title | Synthesis and evaluation of stilbene derivatives as a potential imaging agent of amyloid plaques | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rhee, Hakjune | - |
dc.identifier.doi | 10.1016/j.bmc.2010.06.044 | - |
dc.identifier.scopusid | 2-s2.0-78449235460 | - |
dc.identifier.wosid | 000283649900003 | - |
dc.identifier.bibliographicCitation | Bioorganic and Medicinal Chemistry, v.18, no.22, pp.7724 - 7730 | - |
dc.relation.isPartOf | Bioorganic and Medicinal Chemistry | - |
dc.citation.title | Bioorganic and Medicinal Chemistry | - |
dc.citation.volume | 18 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 7724 | - |
dc.citation.endPage | 7730 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | SOLID-PHASE SYNTHESIS | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordPlus | PET | - |
dc.subject.keywordPlus | TANGLES | - |
dc.subject.keywordPlus | LIGANDS | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease (AD) | - |
dc.subject.keywordAuthor | beta-Amyloid peptide (A beta) | - |
dc.subject.keywordAuthor | Fluorescence imaging probe | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0968089610005729?via%3Dihub | - |
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