The compound isolated from the leaves of Phyllostachys nigra protects oxidative stress-induced retinal ganglion cells death
DC Field | Value | Language |
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dc.contributor.author | Lee, Hee Ju | - |
dc.contributor.author | Kim, Kyung-A | - |
dc.contributor.author | Kang, Kui Dong | - |
dc.contributor.author | Lee, Eun Ha | - |
dc.contributor.author | Kim, Chul Young | - |
dc.contributor.author | Um, Byung Hun | - |
dc.contributor.author | Jung, Sang Hoon | - |
dc.date.accessioned | 2021-06-23T13:05:12Z | - |
dc.date.available | 2021-06-23T13:05:12Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2010-06 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/39772 | - |
dc.description.abstract | This study was performed to determine whether the compound isolated from Phyllostachys nigra could attenuate oxidative stress in transformed retinal ganglion cells (RGC-5 cells) death. RGC-5 cells in culture were given two different insults such as 1-buthionine-(S,R)-sulfoximine (BSO) plus glutamate for 24 h or hydrogen peroxide for 24 h, after which cell survival were measured. Among the four systematic fractions tested, ethyl acetate fraction showed a significantly higher inhibition which was in a concentration dependent manner. Eight compounds were isolated from ethyl acetate fraction of P. nigra using preparative RP-HPLC and Sephadex LH-20 column chromatography. Their chemical structures were elucidated by chemical and spectral analysis as isoorientin (1), orientin (2), vitexin (3), cis-coumaric acid (4), p-coumaric acid (5), luteolin 6-C-(6 ''-O-trans-caffeoylglucoside) (6), vittariflavone (7) and tricin (8). The luteolin 6-C-(6 ''-O-trans-caffeoylglucoside) (compound 6) significantly attenuated the negative effects of BSO plus glutamate or hydrogen peroxide to RGC-5 cells. Treatment of the RGC-5 cells with compound 6 reduced the reactive oxygen species (ROS) as quantified using 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA). This compound also replenished the reduced glutathione level. In conclusion, these results implicate that compound 6 isolated from P. nigra could be used as a leading compounds for retinal disease via anti-oxidative effects. (C) 2010 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | The compound isolated from the leaves of Phyllostachys nigra protects oxidative stress-induced retinal ganglion cells death | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chul Young | - |
dc.identifier.doi | 10.1016/j.fct.2010.03.052 | - |
dc.identifier.scopusid | 2-s2.0-77952878710 | - |
dc.identifier.wosid | 000278768500043 | - |
dc.identifier.bibliographicCitation | FOOD AND CHEMICAL TOXICOLOGY, v.48, no.6, pp.1721 - 1727 | - |
dc.relation.isPartOf | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.citation.title | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.citation.volume | 48 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1721 | - |
dc.citation.endPage | 1727 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | OPEN-ANGLE GLAUCOMA | - |
dc.subject.keywordPlus | OPTIC-NERVE HEAD | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | NEUROPATHY | - |
dc.subject.keywordPlus | REDUCTION | - |
dc.subject.keywordAuthor | Phyllostachys nigra | - |
dc.subject.keywordAuthor | Luteolin 6-C-(6 &apos | - |
dc.subject.keywordAuthor | &apos | - |
dc.subject.keywordAuthor | -O-trans-caffeoylglucoside) | - |
dc.subject.keywordAuthor | RGC-5 | - |
dc.subject.keywordAuthor | ROS | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0278691510002127?via%3Dihub | - |
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