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Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Gu, Su Jin | - |
| dc.contributor.author | Lee, Jae Kyun | - |
| dc.contributor.author | Pae, Ae Nim | - |
| dc.contributor.author | Chung, Hye Jin | - |
| dc.contributor.author | Rhim, Hyewon | - |
| dc.contributor.author | Han, So Yeob | - |
| dc.contributor.author | Min, Sun-Joon | - |
| dc.contributor.author | Cho, Yong Seo | - |
| dc.date.accessioned | 2021-06-23T13:06:03Z | - |
| dc.date.available | 2021-06-23T13:06:03Z | - |
| dc.date.issued | 2010-05 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.issn | 1464-3405 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/39813 | - |
| dc.description.abstract | We have synthesized and biologically evaluated 1,4-diazepane derivatives as T-type calcium channel blockers. In this study, we discovered compound 4s, a potential T-type calcium channel blocker with good selectivity over hERG and N-type calcium channels. In addition, it exhibited favorable pharmacokinetic characteristics for further investigation of T-type calcium channel related diseases. (C) 2010 Elsevier Ltd. All rights reserved. | - |
| dc.format.extent | 4 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | Pergamon Press Ltd. | - |
| dc.title | Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers | - |
| dc.type | Article | - |
| dc.publisher.location | 영국 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2010.03.084 | - |
| dc.identifier.scopusid | 2-s2.0-77950943791 | - |
| dc.identifier.wosid | 000276816600001 | - |
| dc.identifier.bibliographicCitation | Bioorganic and Medicinal Chemistry Letters, v.20, no.9, pp 2705 - 2708 | - |
| dc.citation.title | Bioorganic and Medicinal Chemistry Letters | - |
| dc.citation.volume | 20 | - |
| dc.citation.number | 9 | - |
| dc.citation.startPage | 2705 | - |
| dc.citation.endPage | 2708 | - |
| dc.type.docType | Article | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | sci | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.subject.keywordPlus | CA2+ CHANNELS | - |
| dc.subject.keywordPlus | DESIGN | - |
| dc.subject.keywordPlus | ANTAGONISTS | - |
| dc.subject.keywordPlus | MIBEFRADIL | - |
| dc.subject.keywordPlus | DISCOVERY | - |
| dc.subject.keywordAuthor | T-type calcium channel blockers | - |
| dc.subject.keywordAuthor | 1,4-Diazepane | - |
| dc.subject.keywordAuthor | Pharmacokinetics | - |
| dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0960894X10004257?via%3Dihub | - |
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Related Researcher
- Min, Sun Joon
- ERICA 공학대학 (ERICA 에너지바이오학과)