Inhibitory Effects of Dicaffeoylquinic Acids from Artemisia dubia on Aldo-keto Reductase Family 1B10
DC Field | Value | Language |
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dc.contributor.author | Lee, Hee Ju | - |
dc.contributor.author | Lee, Joo Young | - |
dc.contributor.author | Kim, Sang Min | - |
dc.contributor.author | Nho, Chu Won | - |
dc.contributor.author | Jung, Sang Hoon | - |
dc.contributor.author | Song, Dae-Geun | - |
dc.contributor.author | Kim, Chul Young | - |
dc.contributor.author | Pan, Cheol-Ho | - |
dc.date.accessioned | 2021-06-23T13:41:49Z | - |
dc.date.available | 2021-06-23T13:41:49Z | - |
dc.date.issued | 2010-12 | - |
dc.identifier.issn | 2468-0834 | - |
dc.identifier.issn | 2468-0842 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/40133 | - |
dc.description.abstract | The ethyl acetate fraction of Artemisia dubia showed a potent inhibitory activity on recombinant human AKR1B10 (rh AKR1B10). Due to its potency, subsequent purification of ethyl acetate fraction led to seven compounds including five dicaffeoylquinic acid (DCQA) derivatives. Compounds were identified as 3,4-dihydroxybenzoic acid (1), quercetin 3-O-β-glucose (2), 3,4- DCQA (3), 3,5-DCQA (4), 4,5-DCQA (5), 3,5-DCQA methyl ester (6), and 4,5-DCQA methyl ester (7). A series of DCQA derivatives (3-7) showed inhibitory activity on rhAKR1B10 in the range of IC50 1.24-2.29 μM, whereas 3,4-dihydroxybenzoic acid and quercetin 3-O-β-glucose showed no inhibitory activity on rhAKR1B10. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국응용생명화학회 | - |
dc.title | Inhibitory Effects of Dicaffeoylquinic Acids from Artemisia dubia on Aldo-keto Reductase Family 1B10 | - |
dc.type | Article | - |
dc.publisher.location | 싱가폴 | - |
dc.identifier.doi | 10.3839/jksabc.2010.125 | - |
dc.identifier.wosid | 000286407900025 | - |
dc.identifier.bibliographicCitation | Applied Biological Chemistry, v.53, no.6, pp 826 - 830 | - |
dc.citation.title | Applied Biological Chemistry | - |
dc.citation.volume | 53 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 826 | - |
dc.citation.endPage | 830 | - |
dc.identifier.kciid | ART001514785 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordAuthor | AKR1B10 | - |
dc.subject.keywordAuthor | aldose reductase-like | - |
dc.subject.keywordAuthor | anticancer | - |
dc.subject.keywordAuthor | DCQA | - |
dc.subject.keywordAuthor | dicaffeoylquinic acid | - |
dc.subject.keywordAuthor | Artemisia dubia | - |
dc.identifier.url | https://applbiolchem.springeropen.com/articles/10.3839/jksabc.2010.125 | - |
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