Hydrotropic oligomer-conjugated glycol chitosan as a carrier of paclitaxel: Synthesis, characterization, and in vivo biodistribution
DC Field | Value | Language |
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dc.contributor.author | Saravanakumar, G. | - |
dc.contributor.author | Min, Kyung Hyun | - |
dc.contributor.author | Min, Dong Sik | - |
dc.contributor.author | Kim, Ah Young | - |
dc.contributor.author | Lee, Chang-Moon | - |
dc.contributor.author | Cho, Yong Woo | - |
dc.contributor.author | Lee, Sang Cheon | - |
dc.contributor.author | Kim, Kwangmeyung | - |
dc.contributor.author | Jeong, Seo Young | - |
dc.contributor.author | Park, Kinam | - |
dc.contributor.author | Park, Jae Hyung | - |
dc.contributor.author | Kwon, Ick Chan | - |
dc.date.accessioned | 2021-06-23T14:39:30Z | - |
dc.date.available | 2021-06-23T14:39:30Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2009-12 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/40595 | - |
dc.description.abstract | Development of successful formulations for poorly water-soluble drugs remains a longstanding critical and challenging issue in cancer therapy. As a potential drug carrier of paclitaxel, hydrotropic oligomer-glycol chitosan (HO-GC) was synthesized by chemical conjugation of the N,N-diethylnicotinamide-based oligomer, uniquely designed for enhancing the aqueous solubility of paclitaxel, to the backbone of glycol chitosan. Owing to its amphiphilicity, the conjugate formed self-assembled nanoparticles with a mean diameter of 313 +/- 13 nm in a phosphate-buffered saline (PBS, pH 7.4 at 37 degrees C). HO-GC nanoparticles maintained their structure for up to 50 days in PBS. They could encapsulate a high quantity (20 wt.%) of paclitaxel (M) with a maximum drug-loading efficiency of 97%, due to the presence of hydrotropic inner cores. When HO-GC-PTX particles were exposed to the 0.1 M sodium salicylate solution in PBS (pH 7.4), PTX was released from nanoparticles in a sustained manner. From the cytotoxicity test, it was confirmed that HO-GC-PTX nanoparticles showed lower cytotoxicity than free PTX formulation in 50%/50% Cremophor EL/ethanol mixture. The optical imaging results indicated that near-infrared fluorescence dye (Cy5.5)-labeled HO-GC-PTX showed an excellent tumor specificity in SCC7 tumor-bearing mice, due to the enhanced permeation and retention effect. Overall, HO-GC-PTX nanoparticles might be a promising carrier for PTX delivery in cancer therapy. (C) 2009 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Hydrotropic oligomer-conjugated glycol chitosan as a carrier of paclitaxel: Synthesis, characterization, and in vivo biodistribution | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Yong Woo | - |
dc.identifier.doi | 10.1016/j.jconrel.2009.06.015 | - |
dc.identifier.scopusid | 2-s2.0-70449705990 | - |
dc.identifier.wosid | 000273081600006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CONTROLLED RELEASE, v.140, no.3, pp.210 - 217 | - |
dc.relation.isPartOf | JOURNAL OF CONTROLLED RELEASE | - |
dc.citation.title | JOURNAL OF CONTROLLED RELEASE | - |
dc.citation.volume | 140 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 210 | - |
dc.citation.endPage | 217 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | SELF-ASSEMBLED NANOPARTICLES | - |
dc.subject.keywordPlus | BEARING 5-BETA-CHOLANIC ACID | - |
dc.subject.keywordPlus | ANTITUMOR EFFICACY | - |
dc.subject.keywordPlus | POLYMERIC MICELLES | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | FORMULATION | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | SOLUBILITY | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordAuthor | Hydrotropic oligomer | - |
dc.subject.keywordAuthor | Glycol chitosan | - |
dc.subject.keywordAuthor | Self-assembled nanoparticles | - |
dc.subject.keywordAuthor | Paclitaxel | - |
dc.subject.keywordAuthor | Cancer therapy | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0168365909004246?via%3Dihub | - |
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