gamma-Secretase Inhibitor Reduces Allergic Pulmonary Inflammation by Modulating Th1 and Th2 Responses
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Jin Hyun | - |
dc.contributor.author | Kim, Byung Soo | - |
dc.contributor.author | Uhm, Tae Gi | - |
dc.contributor.author | Lee, Shin-Hwa | - |
dc.contributor.author | Lee, Gap Ryol | - |
dc.contributor.author | Park, Choon-Sik | - |
dc.contributor.author | Chung, Il Yup | - |
dc.date.accessioned | 2021-06-23T15:38:37Z | - |
dc.date.available | 2021-06-23T15:38:37Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2009-05 | - |
dc.identifier.issn | 1073-449X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/41202 | - |
dc.description.abstract | Rationale: gamma-Secretase inhibitor (GSI) has been used to effectively block Notch signaling, which is implicated in the differentiation and functional regulation of T helper (Th) effector cells. In asthma, a subset of CD4(+) T cells is believed to initiate and perpetuate the disease. Objectives: The aim of this study was to evaluate the therapeutic potential of GSI against allergic asthma. Methods: GSI was administered to an ovalbumin-sensitized mouse via an intranasal route at the time of ovalbumin challenge. Measurements and Main Results: The administration of GSI inhibits asthma phenotypes, including eosinophilic airway inflammation, goblet cell metaplasia, methacholine-induced airway hyperresponsiveness, and serum IgE production. GSI treatment of bronchoalveolar lavage cells stimulated via TCR or non-TCR pathways led to a decrease in Th2 cytokine production with a concomitant increase in Th1 cytokine secretion. Expression of Hes-1, a target of Notch signaling, was down-regulated in conjunction with a reduction of Notch intracellular domain and GATA-3 levels after GSI treatment of bronchoalveolar lavage cells. GSI treatment resulted in an inhibition of NF-kappa B activation, and combined treatment with GSI and an NF-kappa B inhibitor augmented IFN-gamma production in a synergistic manner. Conclusions: These data suggest that GSI directly regulates Th1 and Th2 responses in allergic pulmonary inflammation through a Notch signaling-dependent pathway and that GSI is of high therapeutic value for treating asthma by inhibiting airway inflammatory responses. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | American Thoracic Society | - |
dc.title | gamma-Secretase Inhibitor Reduces Allergic Pulmonary Inflammation by Modulating Th1 and Th2 Responses | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chung, Il Yup | - |
dc.identifier.doi | 10.1164/rccm.200806-893OC | - |
dc.identifier.scopusid | 2-s2.0-65649149442 | - |
dc.identifier.wosid | 000265951500005 | - |
dc.identifier.bibliographicCitation | American Journal of Respiratory and Critical Care Medicine, v.179, no.10, pp.875 - 882 | - |
dc.relation.isPartOf | American Journal of Respiratory and Critical Care Medicine | - |
dc.citation.title | American Journal of Respiratory and Critical Care Medicine | - |
dc.citation.volume | 179 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 875 | - |
dc.citation.endPage | 882 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Critical Care Medicine | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | NOTCH SIGNALING PATHWAY | - |
dc.subject.keywordPlus | CD4(+) T-CELLS | - |
dc.subject.keywordPlus | AIRWAY INFLAMMATION | - |
dc.subject.keywordPlus | GATA3 EXPRESSION | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | CYTOKINE EXPRESSION | - |
dc.subject.keywordPlus | LINEAGE COMMITMENT | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordAuthor | asthma | - |
dc.subject.keywordAuthor | GATA-3 | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | notch | - |
dc.subject.keywordAuthor | gamma-secretase inhibitor | - |
dc.identifier.url | https://www.atsjournals.org/doi/full/10.1164/rccm.200806-893OC | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.