HY253, a novel compound isolated from Aralia continentalis, induces apoptosis via cytochrome c-mediated intrinsic pathway in HeLa cells
DC Field | Value | Language |
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dc.contributor.author | Oh, Ha Lim | - |
dc.contributor.author | Lim, Haeyoung | - |
dc.contributor.author | Park, Younghee | - |
dc.contributor.author | Lim, Yoongho | - |
dc.contributor.author | Koh, Hyun Chul | - |
dc.contributor.author | Cho, Youl-Hee | - |
dc.contributor.author | Lee, Chul-Hoon | - |
dc.date.accessioned | 2021-06-23T16:02:09Z | - |
dc.date.available | 2021-06-23T16:02:09Z | - |
dc.date.issued | 2009-02 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.issn | 1464-3405 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/41398 | - |
dc.description.abstract | This study was aimed to elucidate the novel structure of HY253 isolated from the roots of Aralia continentalis and to evaluate its detailed mechanisms on apoptotic induction in HY253-treated HeLa cells. The structure of HY253 was elucidated based on the interpretation of the NMR spectra, as 7,8a-divinyl-2,4a,4b,5,6,7,8,8a, 9,9a-decahydro-1H-fluorene-2,4a,4b,9a-tetraol. The TUNEL assay using flow cytometer revealed an appreciable apoptotic induction in HeLa cells treated with 100 mu M of HY253 for 48 h. This apoptotic induction is associated with cytochrome c release from mitochondria, via up-regulation of pro-apoptotic Bcl-2 proteins, such as Bax and Bak, which, in turn, resulted in the activation of caspase-8, -9 and -3, and the cleavage of poly(ADP-ribose) polymerase (PARP). (C) 2008 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 3 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.title | HY253, a novel compound isolated from Aralia continentalis, induces apoptosis via cytochrome c-mediated intrinsic pathway in HeLa cells | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.bmcl.2008.12.009 | - |
dc.identifier.scopusid | 2-s2.0-58549091839 | - |
dc.identifier.wosid | 000262707000049 | - |
dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry Letters, v.19, no.3, pp 797 - 799 | - |
dc.citation.title | Bioorganic & Medicinal Chemistry Letters | - |
dc.citation.volume | 19 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 797 | - |
dc.citation.endPage | 799 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | DEPENDENT KINASE INHIBITOR | - |
dc.subject.keywordPlus | CYCLE ARREST | - |
dc.subject.keywordPlus | POLY(ADP-RIBOSE) POLYMERASE | - |
dc.subject.keywordPlus | STREPTOMYCES SP | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | PROTEASE | - |
dc.subject.keywordPlus | CLEAVAGE | - |
dc.subject.keywordPlus | MCS-C2 | - |
dc.subject.keywordPlus | BCL-2 | - |
dc.subject.keywordAuthor | Aralia continentalis | - |
dc.subject.keywordAuthor | Apoptotic induction | - |
dc.subject.keywordAuthor | Cytochrome c | - |
dc.subject.keywordAuthor | HeLa cells | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0960894X0801514X?via%3Dihub | - |
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