Protection of Cardiomyocytes from Ischemic/Hypoxic Cell Death via Drbp1 and pMe(2)GlyDH in Cardio-specific ARC Transgenic Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pyo, Jong-Ok | - |
dc.contributor.author | Nah, Jihoon | - |
dc.contributor.author | Kim, Hyo-Jin | - |
dc.contributor.author | Chang, Jae-Woong | - |
dc.contributor.author | Song, Young-Wha | - |
dc.contributor.author | Yang, Dong-Kwon | - |
dc.contributor.author | Jo, Dong-Gyu | - |
dc.contributor.author | Kim, Hyung-Ryong | - |
dc.contributor.author | Chae, Han-Jung | - |
dc.contributor.author | Chae, Soo-Wan | - |
dc.contributor.author | Hwang, Seung-Yong | - |
dc.contributor.author | Kim, Seung-Jun | - |
dc.contributor.author | Kim, Hyo-Joon | - |
dc.contributor.author | Cho, Chunghee | - |
dc.contributor.author | Oh, Chang-Gyu | - |
dc.contributor.author | Park, Woo Jin | - |
dc.contributor.author | Jung, Yong-Keun | - |
dc.date.accessioned | 2021-06-23T17:02:04Z | - |
dc.date.available | 2021-06-23T17:02:04Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2008-11 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/42001 | - |
dc.description.abstract | The ischemic death of cardiomyocytes is associated in heart disease and heart failure. However, the molecular mechanism underlying ischemic cell death is not well defined. To examine the function of apoptosis repressor with a caspase recruitment domain (ARC) in the ischemic/hypoxic damage of cardiomyocytes, we generated cardio-specific ARC transgenic mice using a mouse alpha-myosin heavy chain promoter. Compared with the control, the hearts of ARC transgenic mice showed a 3-fold overexpression of ARC. Langendoff preparation showed that the hearts isolated from ARC transgenic mice exhibited improved recovery of contractile performance during reperfusion. The cardiomyocytes cultured from neonatal ARC transgenic mice were significantly resistant to hypoxic cell death. Furthermore, the ARC C-terminal calcium-binding domain was as potent to protect cardiomyocytes from hypoxic cell death as ARC. Genome-wide RNA expression profiling uncovered a list of genes whose expression was changed (>2-fold) in ARC transgenic mice. Among them, expressional regulation of developmentally regulated RNA-binding protein 1 (Drbp1) or the dimethylglycine dehydrogenase precursor (pMe(2)GlyDH) affected hypoxic death of cardiomyocytes. These results suggest that ARC may protect cardiomyocytes from hypoxic cell death by regulating its downstream, Drbp1 and pMe2GlyDH, shedding new insights into the protection of heart from hypoxic damages. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | American Society for Biochemistry and Molecular Biology Inc. | - |
dc.title | Protection of Cardiomyocytes from Ischemic/Hypoxic Cell Death via Drbp1 and pMe(2)GlyDH in Cardio-specific ARC Transgenic Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Seung-Yong | - |
dc.identifier.doi | 10.1074/jbc.M804209200 | - |
dc.identifier.scopusid | 2-s2.0-57649187088 | - |
dc.identifier.wosid | 000260544800026 | - |
dc.identifier.bibliographicCitation | Journal of Biological Chemistry, v.283, no.45, pp.30707 - 30714 | - |
dc.relation.isPartOf | Journal of Biological Chemistry | - |
dc.citation.title | Journal of Biological Chemistry | - |
dc.citation.volume | 283 | - |
dc.citation.number | 45 | - |
dc.citation.startPage | 30707 | - |
dc.citation.endPage | 30714 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | CASPASE RECRUITMENT DOMAIN | - |
dc.subject.keywordPlus | APOPTOSIS REPRESSOR | - |
dc.subject.keywordPlus | REPERFUSION INJURY | - |
dc.subject.keywordPlus | ACTIVATED AKT | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | HEART | - |
dc.subject.keywordPlus | CARDIOPROTECTION | - |
dc.subject.keywordPlus | CARDIOMYOPATHY | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0021925820646439?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.