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Selective nosylation of 1-phenylpropane-1,3-diol and perchloric acid mediated Friedel-Crafts alkylation: Key steps for the new and straightforward synthesis of tolterodine
Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | De Castro, Kathlia A. | - |
| dc.contributor.author | Rhee, Hakjune | - |
| dc.date.accessioned | 2021-06-23T17:38:16Z | - |
| dc.date.available | 2021-06-23T17:38:16Z | - |
| dc.date.issued | 2008-06 | - |
| dc.identifier.issn | 0039-7881 | - |
| dc.identifier.issn | 1437-210X | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/42372 | - |
| dc.description.abstract | We have developed a new and straightforward synthesis of racemic tolterodine [NN-diisopropyl-3-(2-hydroxy-5-methyl-phenyl)-3-phenylpropanamine]. The synthesis involves selective nosylation on the primary alcohol of 1-phenylpropane-1,3-diol using 4-nitrobenzenesulfonyl chloride, subsequent diisopropylamine substitution, and Friedel-Crafts alkylation using aqueous perchloric acid. | - |
| dc.format.extent | 4 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | Georg Thieme Verlag | - |
| dc.title | Selective nosylation of 1-phenylpropane-1,3-diol and perchloric acid mediated Friedel-Crafts alkylation: Key steps for the new and straightforward synthesis of tolterodine | - |
| dc.type | Article | - |
| dc.publisher.location | 독일 | - |
| dc.identifier.doi | 10.1055/s-2008-1067084 | - |
| dc.identifier.scopusid | 2-s2.0-46649084036 | - |
| dc.identifier.wosid | 000257284900004 | - |
| dc.identifier.bibliographicCitation | Synthesis, no.12, pp 1841 - 1844 | - |
| dc.citation.title | Synthesis | - |
| dc.citation.number | 12 | - |
| dc.citation.startPage | 1841 | - |
| dc.citation.endPage | 1844 | - |
| dc.type.docType | Article | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.subject.keywordPlus | MUSCARINIC RECEPTOR ANTAGONIST | - |
| dc.subject.keywordPlus | ASYMMETRIC TOTAL-SYNTHESIS | - |
| dc.subject.keywordPlus | EFFICIENT ROUTE | - |
| dc.subject.keywordPlus | ALCOHOLS | - |
| dc.subject.keywordPlus | TOSYLATION | - |
| dc.subject.keywordPlus | SULFONYLATION | - |
| dc.subject.keywordPlus | OXYBUTYNIN | - |
| dc.subject.keywordPlus | CHLORIDE | - |
| dc.subject.keywordAuthor | drugs | - |
| dc.subject.keywordAuthor | diol | - |
| dc.subject.keywordAuthor | selective sulfonation | - |
| dc.subject.keywordAuthor | nucleophilic substitution | - |
| dc.subject.keywordAuthor | Friedel-Crafts alkylation | - |
| dc.identifier.url | https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-2008-1067084 | - |
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Related Researcher
- Rhee, Hak june
- ERICA 공학대학 (ERICA 에너지바이오학과)