U-shaped dose response in vasomotor tone: A mixed result of heterogenic response of multiple cells to xenobiotics
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, Ok-Nam | - |
dc.contributor.author | Lim, Kyung-Min | - |
dc.contributor.author | Han, Jee-Yeon | - |
dc.contributor.author | Jung, Byoung-In | - |
dc.contributor.author | Lee, Jin-Young | - |
dc.contributor.author | Noh, Ji-Yoon | - |
dc.contributor.author | Chung, Seung-Min | - |
dc.contributor.author | Lee, Moo-Yeol | - |
dc.contributor.author | Lee, Joo-Young | - |
dc.contributor.author | Chung, Jin-Ho | - |
dc.date.accessioned | 2021-06-23T17:40:40Z | - |
dc.date.available | 2021-06-23T17:40:40Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2008-05 | - |
dc.identifier.issn | 1096-6080 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/42521 | - |
dc.description.abstract | U-shaped response has been frequently encountered in various biological areas including epidemiology, toxicology, and oncology. Despite its frequent observation, the theory of U-shaped response has been crippled by the lack of a robust mechanism underlying and incomplete in vitro and in vivo correlation. In the present study, a novel mechanism is provided for a U-shaped response, based on the findings of agonist-induced vasomotor tone change affected by menadione (MEN) (synthetic vitamin K-3), a reactive oxygen species generator, and arsenic, an environmental pollutant, which showed typical U-shaped responses in both in vitro aortic contractile response and in vivo blood pressure. U-shaped responses by MEN and arsenic were a combined result from heterogenic susceptibilities and responses of multiple target cells composing blood vessels, that is, endothelium and smooth muscle. Notably, endothelium, a regulator of vasomotor tone, was primarily affected by low-dose stimuli, whereas smooth muscle, an effector of vascular contraction, was affected later by high-dose. The dysfunction of smooth muscle was produced by high-dose MEN-induced hydrogen peroxide, resulting in the attenuation of vascular contractile reactivity, whereas low-dose MEN-induced superoxide led to the quenching of vasodilatory nitric oxide in endothelial cells, resulting in the enhancement of vasoconstriction. This mechanistic theory, the difference in susceptibilities and responses to a common stimulus between regulator and effector components of a system, could give a new insight into the explanation of various U-shaped responses and provide a new evidence for the need of the risk assessment of toxicants with a wider dose range. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Oxford University Press | - |
dc.title | U-shaped dose response in vasomotor tone: A mixed result of heterogenic response of multiple cells to xenobiotics | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, Ok-Nam | - |
dc.identifier.doi | 10.1093/toxsci/kfn023 | - |
dc.identifier.scopusid | 2-s2.0-42149107390 | - |
dc.identifier.wosid | 000254955500019 | - |
dc.identifier.bibliographicCitation | Toxicological Sciences, v.103, no.1, pp.181 - 190 | - |
dc.relation.isPartOf | Toxicological Sciences | - |
dc.citation.title | Toxicological Sciences | - |
dc.citation.volume | 103 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 181 | - |
dc.citation.endPage | 190 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | ENDOTHELIAL DYSFUNCTION | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | OXIDASE ACTIVATION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | SUPEROXIDE | - |
dc.subject.keywordPlus | HORMESIS | - |
dc.subject.keywordPlus | VASOCONSTRICTION | - |
dc.subject.keywordPlus | RELAXATION | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | OXYGEN | - |
dc.subject.keywordAuthor | U-shaped dose response | - |
dc.subject.keywordAuthor | vasoconstriction | - |
dc.subject.keywordAuthor | arsenic | - |
dc.subject.keywordAuthor | menadione | - |
dc.subject.keywordAuthor | endothelial cells | - |
dc.subject.keywordAuthor | smooth muscle cells | - |
dc.subject.keywordAuthor | heterogenic responses | - |
dc.subject.keywordAuthor | risk assessment | - |
dc.identifier.url | https://academic.oup.com/toxsci/article/103/1/181/1695187 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.