Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease
DC Field | Value | Language |
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dc.contributor.author | Ryoo, Soo-Ryoon | - |
dc.contributor.author | Cho, Hyun-Jeong | - |
dc.contributor.author | Lee, Hye-Won | - |
dc.contributor.author | Jeong, Hey Kyeong | - |
dc.contributor.author | Radnaabazar, Chinzorig | - |
dc.contributor.author | Kim, Yeun-Soo | - |
dc.contributor.author | Kim, Min-Jeong | - |
dc.contributor.author | Son, Mi-Young | - |
dc.contributor.author | Seo, Hyemyung | - |
dc.contributor.author | Chung, Sul-Hee | - |
dc.contributor.author | Song, Woo-Joo | - |
dc.date.accessioned | 2021-06-23T18:02:29Z | - |
dc.date.available | 2021-06-23T18:02:29Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2008-03 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/42616 | - |
dc.description.abstract | Most individuals with Down Syndrome (DS) show an early-onset of Alzheimer's disease ( AD), which potentially results from the presence of an extra copy of a segment of chromosome 21. Located on chromosome 21 are the genes that encode beta-amyloid (A beta) precursor protein (APP), a key protein involved in the pathogenesis of AD, and dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A (DYRK1A), a proline-directed protein kinase that plays a critical role in neurodevelopment. Here, we describe a potential mechanism for the regulation of AD pathology in DS brains by DYRK1A-mediated phosphorylation of APP. We show that APP is phosphorylated at Thr668 by DYRK1A in vitro and in mammalian cells. The amounts of phospho-APP and Ab are increased in the brains of transgenic mice that over-express the human DYRK1A protein. Furthermore, we show that the amounts of phospho-APP as well as those of APP and DYRK1A are elevated in human DS brains. Taken together, these results reveal a potential regulatory link between APP and DYRK1A in DS brains, and suggest that the overexpression of DYRK1A in DS may play a role in accelerating AD pathogenesis through phosphorylation of APP. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seo, Hyemyung | - |
dc.identifier.doi | 10.1111/j.1471-4159.2007.05075.x | - |
dc.identifier.scopusid | 2-s2.0-39749196069 | - |
dc.identifier.wosid | 000253257200016 | - |
dc.identifier.bibliographicCitation | Journal of Neurochemistry, v.104, no.5, pp.1333 - 1344 | - |
dc.relation.isPartOf | Journal of Neurochemistry | - |
dc.citation.title | Journal of Neurochemistry | - |
dc.citation.volume | 104 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1333 | - |
dc.citation.endPage | 1344 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | SYNDROME CRITICAL REGION | - |
dc.subject.keywordPlus | CYTOPLASMIC DOMAIN | - |
dc.subject.keywordPlus | HUMAN HOMOLOG | - |
dc.subject.keywordPlus | TRANSGENIC MODELS | - |
dc.subject.keywordPlus | GAMMA-SECRETASE | - |
dc.subject.keywordPlus | DYRK1A | - |
dc.subject.keywordPlus | MINIBRAIN | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | APP | - |
dc.subject.keywordAuthor | beta-amyloid | - |
dc.subject.keywordAuthor | Down syndrome | - |
dc.subject.keywordAuthor | DYRK1A | - |
dc.subject.keywordAuthor | phosphorylation | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2007.05075.x | - |
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