Hepatoprotective effect of Grifola frondosa water extract on carbon tetrachloride-induced liver injury in rats
DC Field | Value | Language |
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dc.contributor.author | Lee, Jong-Sulk | - |
dc.contributor.author | Kim, Han-Sup | - |
dc.contributor.author | Lee, Yoon-Joo | - |
dc.contributor.author | Yong, Cheol-Soon | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Han, Gi-Dong | - |
dc.contributor.author | Vim, Jung-Ae | - |
dc.contributor.author | Lee, Jae-Sung | - |
dc.date.accessioned | 2021-06-23T18:03:48Z | - |
dc.date.available | 2021-06-23T18:03:48Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2008-02 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/42690 | - |
dc.description.abstract | The present study aimed at assessing the protective effect of water extract from fruit body of the Grifola frondosa (GFW) on carbon tetrachloride (CCl4)-induced hepatotoxicity. Rats orally administered with GFW 0.5, 1.0, 2.0 g/kg for 14 days were treated with CCl4 to induce hepatotoxicity. Pretreatment with GFW remarkably prevented the elevation of serum AST, ALT, ALP, LDH, gamma-GTP, and liver lipid peroxides in CCl4-treated rat and GFW administration in liver injured rats by CC showed significant (p < 0.05) protection of liver as evidenced from normal serum enzymes and malondialdehyde (MDA) levels. In the ultrastructural changes, administration Of CCl4-induced damage of hepatocytes with vacuolation, a highly damaged endoplasmic reticulum, and degenerating nuclei. However, pre-administration with GFW preserved normal ultrastructure of hepatocytes. These results suggest that GFW had an effect to inhibit CCl4-induced liver injury in rat, and that it could be used as an effective hepatoprotective agent against chemical-induced liver damage. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST | - |
dc.title | Hepatoprotective effect of Grifola frondosa water extract on carbon tetrachloride-induced liver injury in rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.scopusid | 2-s2.0-49649089256 | - |
dc.identifier.wosid | 000253922600037 | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE AND BIOTECHNOLOGY, v.17, no.1, pp.203 - 207 | - |
dc.relation.isPartOf | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.title | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.volume | 17 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 203 | - |
dc.citation.endPage | 207 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001237018 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | PLEUROTUS-OSTREATUS | - |
dc.subject.keywordPlus | LENTINUS-EDODES | - |
dc.subject.keywordPlus | KUPFFER CELLS | - |
dc.subject.keywordPlus | FRUIT-BODY | - |
dc.subject.keywordPlus | MAITAKE | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | POLYSACCHARIDE | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | MUSHROOMS | - |
dc.subject.keywordPlus | ANTITUMOR | - |
dc.subject.keywordAuthor | Grifola frondosa | - |
dc.subject.keywordAuthor | carbon tetrachloride (CCl4) | - |
dc.subject.keywordAuthor | hepatoprotection | - |
dc.subject.keywordAuthor | ultrastructural change | - |
dc.subject.keywordAuthor | aspartate aminotransferase (AST)/alanine aminotransferase (ALT) | - |
dc.identifier.url | https://www.koreascience.or.kr/article/JAKO200833338360312.page | - |
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