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Evaluation of skin permeation and accumulation profiles of a highly lipophilic fatty ester

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dc.contributor.authorBhandari, Krishna Hari-
dc.contributor.authorLee, Dong Xun-
dc.contributor.authorNewa, Madhuri-
dc.contributor.authorYoon, Sung Il-
dc.contributor.authorKim, Jung Sun-
dc.contributor.authorKim, Dae Duk-
dc.contributor.authorKim, Jung-Ae-
dc.contributor.authorYoo, Bong Kyo-
dc.contributor.authorWoo, Jong Soo-
dc.contributor.authorLyoo, Won Seok-
dc.contributor.authorLee, Jae Hwi-
dc.contributor.authorChoi, Han Gon-
dc.contributor.authorYong, Chul Soon-
dc.date.accessioned2021-06-23T18:03:53Z-
dc.date.available2021-06-23T18:03:53Z-
dc.date.issued2008-02-
dc.identifier.issn0253-6269-
dc.identifier.issn1976-3786-
dc.identifier.urihttps://scholarworks.bwise.kr/erica/handle/2021.sw.erica/42693-
dc.description.abstractThe aim was to evaluate the skin permeation and accumulation profiles of a highly lipophilic fatty ester using the combination of various permeation enhancing techniques to study the potential of highly lipophilic fatty esters as local topical agents. Permeation and accumulation profiles of ketorolac stearate (C18:0) were studied using solubility improved formulation, supersaturated solution of permeant in enhancer vehicle, lipophilic receptor solution, enhancer pretreatment, and the removal of stratum corneum and delipidization of skins. Impermeability and minimal skin accumulation of ketorolac stearate could delineate a preliminary possibility for designing safer topical agents without systemic absorption.-
dc.format.extent8-
dc.language영어-
dc.language.isoENG-
dc.publisherPHARMACEUTICAL SOC KOREA-
dc.titleEvaluation of skin permeation and accumulation profiles of a highly lipophilic fatty ester-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.doi10.1007/s12272-001-1148-8-
dc.identifier.scopusid2-s2.0-42949137608-
dc.identifier.wosid000253582100018-
dc.identifier.bibliographicCitationARCHIVES OF PHARMACAL RESEARCH, v.31, no.2, pp 242 - 249-
dc.citation.titleARCHIVES OF PHARMACAL RESEARCH-
dc.citation.volume31-
dc.citation.number2-
dc.citation.startPage242-
dc.citation.endPage249-
dc.type.docTypeArticle-
dc.identifier.kciidART001244611-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusHAIRLESS MOUSE SKIN-
dc.subject.keywordPlusTRANSDERMAL DELIVERY-
dc.subject.keywordPlusPROPYLENE-GLYCOL-
dc.subject.keywordPlusPERCUTANEOUS-ABSORPTION-
dc.subject.keywordPlusPENETRATION ENHANCERS-
dc.subject.keywordPlusBARRIER FUNCTION-
dc.subject.keywordPlusALCOHOLS-
dc.subject.keywordPlusINVITRO-
dc.subject.keywordPlusACIDS-
dc.subject.keywordPlusPRODRUGS-
dc.subject.keywordAuthorfatty esters-
dc.subject.keywordAuthorketorolac stearate-
dc.subject.keywordAuthorskin permeation-
dc.subject.keywordAuthorskin accumulation-
dc.subject.keywordAuthorlocal topical agent-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs12272-001-1148-8-
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