Effects of Schisandra lignans on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells
DC Field | Value | Language |
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dc.contributor.author | Yoo, Hye Hyun | - |
dc.contributor.author | Lee, Mijin | - |
dc.contributor.author | Lee, Min Woo | - |
dc.contributor.author | Lim, Sun Young | - |
dc.contributor.author | Shin, Jongheon | - |
dc.contributor.author | Kim, Dong-Hyun | - |
dc.date.accessioned | 2021-06-23T19:41:09Z | - |
dc.date.available | 2021-06-23T19:41:09Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2007-05 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/43754 | - |
dc.description.abstract | Schisandra fruits (Schisandraceae) are often used in traditional medicine and can be taken concomitantly with conventional medicine. In this study, the effects of dibenzocyclooctadiene lignans from Schizandra chinensis on P-gp-mediated efflux were examined to investigate a possible interaction with P-gp substrates. The cellular accumulation of rhodamine-123 in Caco-2 cells was measured with 12 Schisandra lignans. Most compounds resulted in slight or moderate increases of rhodamin-1 23 cellular uptake, indicating their P-gp inhibitory activity. Among them, cleoxyschizandrin exhibited the most potent effect on the accumulation of rhodamine-123. Subsequently, bidirectional transports of digoxin and rhodamine-123 in Caco-2 cells were determined with cleoxyschizandrin, the most active compound for the rhodamine-123 assay. In the bidirectional transport study, apical-to-basal (A-to-B) transports of digoxin and rhodamine- 123 were increased, whereas basal-to-apical (B-to-A) transports were decreased by deoxyschizandrin in concentration- and time-dependent manners. At 50 mu M of deoxyschizandrin, the transport ratios (B-A/A-B) for digoxin and rhodamine-123 were 2.2 and 2.1 compared with the control ratios of 15.2 and 12.2, respectively. These results demonstrated that deoxyschizandrin effectively inhibited the P-gp-mediated efflux in Caco-2 cells, suggesting they could potentially increase the absorption of drugs that can act as a P-gp substrate. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.title | Effects of Schisandra lignans on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Hye Hyun | - |
dc.identifier.doi | 10.1055/s-2007-967178 | - |
dc.identifier.scopusid | 2-s2.0-34250365825 | - |
dc.identifier.wosid | 000246963300006 | - |
dc.identifier.bibliographicCitation | PLANTA MEDICA, v.73, no.5, pp.444 - 450 | - |
dc.relation.isPartOf | PLANTA MEDICA | - |
dc.citation.title | PLANTA MEDICA | - |
dc.citation.volume | 73 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 444 | - |
dc.citation.endPage | 450 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | GOMISIN-A | - |
dc.subject.keywordPlus | DIBENZOCYCLOOCTADIENE LIGNANS | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | HEPATOCARCINOGENESIS | - |
dc.subject.keywordPlus | CYTOCHROME-P450 | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | CHINENSIS | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordPlus | CYP3A4 | - |
dc.subject.keywordPlus | DIET | - |
dc.subject.keywordAuthor | Schisandra chinensis | - |
dc.subject.keywordAuthor | Schisandraceae | - |
dc.subject.keywordAuthor | P-glycoprotein | - |
dc.subject.keywordAuthor | dibenzo-cyclooctadiene lignans | - |
dc.subject.keywordAuthor | deoxyschizandrin | - |
dc.subject.keywordAuthor | Caco-2 cells | - |
dc.identifier.url | https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-2007-967178 | - |
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