Enhanced bioavailability of poorly water-soluble clotrimazole by inclusion with beta-cyclodextrin
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Prabagar, Balakrishnan | - |
dc.contributor.author | Yoo, Bong-Kyu | - |
dc.contributor.author | Woo, Jong-Soo | - |
dc.contributor.author | Kim, Jung-Ae | - |
dc.contributor.author | Rhee, Jong-Dal | - |
dc.contributor.author | Piao, Ming Guan | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Yong, Chul Soon | - |
dc.date.accessioned | 2021-06-23T20:04:33Z | - |
dc.date.available | 2021-06-23T20:04:33Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2007-02 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/43897 | - |
dc.description.abstract | Clotrimazole, a poorly water-soluble antimycotic agent, is a promising agent for various diseases including cancer and sickle cell anemia. To improve the oral bioavailability of clotrimazole, the inclusion compound of clotrimazole with beta-cyclodextrin was prepared by spray-drying method and characterized by phase solubility, differential scanning calorimetry and dissolution. Furthermore, the pharmacolkinetics after oral administration in rats was then performed compared with clotrimazole powder. The solubility of clotrimazole increased linearly as a function of beta-cyclodextrin concentration, resulting in A(L) type phase solubility diagram which revealed a formation of inclusion compound in a molar ratio of 1:2, with the apparent association constant of 230.2 M-1. The dissolution rate of clotrimazole in the inclusion compound increased greatly compared to clotrimazole powder in pH 7.4 phosphate buffer solution. The inclusion compound gave significantly higher initial plasma concentrations, Cmax and AUC of clotrimazole than did clotrimazole powder when they were administered as suspension form, indicating that the drug from inclusion compound could be more orally absorbed in rats. Thus, the oral bioavailability of clotrimazole could be improved markedly by inclusion complexation, possibly due to an increased dissolution rate. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOCIETY KOREA | - |
dc.title | Enhanced bioavailability of poorly water-soluble clotrimazole by inclusion with beta-cyclodextrin | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.1007/BF02977701 | - |
dc.identifier.scopusid | 2-s2.0-33947144756 | - |
dc.identifier.wosid | 000244622700018 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.30, no.2, pp.249 - 254 | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 30 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 249 | - |
dc.citation.endPage | 254 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001183741 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ORAL BIOAVAILABILITY | - |
dc.subject.keywordPlus | ANTIMYCOTIC ACTIVITY | - |
dc.subject.keywordPlus | COMPLEXATION | - |
dc.subject.keywordPlus | DISSOLUTION | - |
dc.subject.keywordPlus | IMPROVEMENT | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordAuthor | clotrimazole | - |
dc.subject.keywordAuthor | inclusion compound | - |
dc.subject.keywordAuthor | bioavailability | - |
dc.subject.keywordAuthor | beta-cyclodextrin | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2FBF02977701 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.