Alpha-tocopheryl succinate sensitizes human colon cancer cells to exisulind-induced apoptosis
DC Field | Value | Language |
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dc.contributor.author | Lim, Soo-Jeong | - |
dc.contributor.author | Lee, Young-Ju | - |
dc.contributor.author | Park, Dae-Hun | - |
dc.contributor.author | Lee, Eunmyong | - |
dc.contributor.author | Choi, Moon-Kyung | - |
dc.contributor.author | Park, Wanseo | - |
dc.contributor.author | Chun, Kyung-Hee | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Cho, Jung Sik | - |
dc.date.accessioned | 2021-06-23T20:04:35Z | - |
dc.date.available | 2021-06-23T20:04:35Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2007-02 | - |
dc.identifier.issn | 1360-8185 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/43898 | - |
dc.description.abstract | Sulindac sulfone (also known as exisulind) and its chemical derivatives are promising anticancer agents capable of inducing apoptosis in a variety of malignant cell types with minimal toxicity to normal cells. Here, we tested the ability of alpha-tocopheryl succinate (TOS), another promising anticancer agent, to sensitize colon cancer cells to exisulind-induced apoptosis. We found that sub-apoptotic doses of TOS greatly enhanced exisulind-induced growth suppression and apoptosis in the HCT116, LoVo and SNU-C4 human colon cancer cell lines. Our results revealed that this was accounted for primarily by an augmented cleavage of poly(ADP-ribose) polymerase (PARP) and enhanced activation of caspase-8, -9 and -3. Pretreatment with z-VAD-FMK (a pan-caspase inhibitor), z-IETD-FMK (a caspase-8 inhibitor) or z-LEHD-FMK (a caspase-9 inhibitor) blocked TOS and exisulind cotreatment-induced PARP cleavage and apoptosis. Furthermore, TOS/exisulind cotreatment induced JNK phosphorylation, while pretreatment with SP600151 (a JNK inhibitor) partially blocked cotreatment-induced caspase-dependent PARP cleavage and apoptosis. Taken together, these findings indicate that TOS sensitizes human colon cancer cells to exisulind-induced apoptosis. Apoptotic synergy induced by exisulind plus TOS seems likely to be mediated through a mechanism involving activation of caspases and JNK. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | Alpha-tocopheryl succinate sensitizes human colon cancer cells to exisulind-induced apoptosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.1007/s10495-006-0620-9 | - |
dc.identifier.scopusid | 2-s2.0-33846524824 | - |
dc.identifier.wosid | 000243765900015 | - |
dc.identifier.bibliographicCitation | APOPTOSIS, v.12, no.2, pp.423 - 431 | - |
dc.relation.isPartOf | APOPTOSIS | - |
dc.citation.title | APOPTOSIS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 423 | - |
dc.citation.endPage | 431 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | SIGNAL-REGULATED KINASE-1/2 | - |
dc.subject.keywordPlus | HUMAN PROSTATE-CANCER | - |
dc.subject.keywordPlus | VITAMIN-E SUCCINATE | - |
dc.subject.keywordPlus | HUMAN LUNG-CANCER | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | SULINDAC DERIVATIVES | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | REACTIVE OXYGEN | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | exisulind | - |
dc.subject.keywordAuthor | alpha-tocopheryl succinate | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | caspase | - |
dc.subject.keywordAuthor | JNK | - |
dc.subject.keywordAuthor | colon cancer | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs10495-006-0620-9 | - |
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