An injected bacterial effector targets chromatin access for transcription factor NF-kappa B to alter transcription of host genes involved in immune responses
DC Field | Value | Language |
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dc.contributor.author | Arbibe, Laurence | - |
dc.contributor.author | Kim, Dong Wook | - |
dc.contributor.author | Batsche, Eric | - |
dc.contributor.author | Pedron, Thierry | - |
dc.contributor.author | Mateescu, Bogdan | - |
dc.contributor.author | Muchardt, Christian | - |
dc.contributor.author | Parsot, Claude | - |
dc.contributor.author | Sansonetti, Philippe J. | - |
dc.date.accessioned | 2021-06-23T20:04:59Z | - |
dc.date.available | 2021-06-23T20:04:59Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2007-01 | - |
dc.identifier.issn | 1529-2908 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/43920 | - |
dc.description.abstract | Phosphorylation of histone H3 at Ser10 increases chromatin accessibility to transcription factor NF-kappa B on a subset of genes involved in immune responses. Here we report that a bacterial pathogen abrogated phosphorylation of histone H3 to 'shape' the transcriptional responses of infected host cells. We identify the Shigella flexneri protein effector OspF as a dually specific phosphatase that dephosphorylated mitogen-activated protein kinases in the nucleus, thus preventing histone H3 phosphorylation at Ser10 in a gene-specific way. That activity of OspF enabled shigella to block the activation of a subset of NF-kappa B-responsive genes, leading to compromised recruitment of polymorphonuclear leukocytes to infected tissues. S. flexneri has thus evolved the capacity to precisely modulate host cell epigenetic 'information' as a strategy for repressing innate immunity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | An injected bacterial effector targets chromatin access for transcription factor NF-kappa B to alter transcription of host genes involved in immune responses | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Dong Wook | - |
dc.identifier.doi | 10.1038/ni1423 | - |
dc.identifier.scopusid | 2-s2.0-33846958783 | - |
dc.identifier.wosid | 000242934400013 | - |
dc.identifier.bibliographicCitation | NATURE IMMUNOLOGY, v.8, no.1, pp.47 - 56 | - |
dc.relation.isPartOf | NATURE IMMUNOLOGY | - |
dc.citation.title | NATURE IMMUNOLOGY | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 47 | - |
dc.citation.endPage | 56 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | MAP KINASE | - |
dc.subject.keywordPlus | HISTONE H3 | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | PHOSPHOACETYLATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | PHOSPHATASES | - |
dc.subject.keywordPlus | SPECIFICITY | - |
dc.subject.keywordAuthor | SHIGELLA-FLEXNERI | - |
dc.subject.keywordAuthor | MAP KINASE | - |
dc.subject.keywordAuthor | HISTONE H3 | - |
dc.subject.keywordAuthor | EPITHELIAL-CELLS | - |
dc.subject.keywordAuthor | ACTIVATION | - |
dc.subject.keywordAuthor | EXPRESSION | - |
dc.subject.keywordAuthor | PHOSPHOACETYLATION | - |
dc.subject.keywordAuthor | PHOSPHORYLATION | - |
dc.subject.keywordAuthor | RECRUITMENT | - |
dc.subject.keywordAuthor | SECRETION | - |
dc.identifier.url | https://www.nature.com/articles/ni1423 | - |
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