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Total synthesis of paecilomycine A
- Authors
- Min, Sun-Joon; Danishefsky, Samuel J.
- Issue Date
- Mar-2007
- Publisher
- John Wiley & Sons Ltd.
- Keywords
- Diels-Alder reaction; natural products; Pauson-Khand reaction; total synthesis
- Citation
- Angewandte Chemie - International Edition, v.46, no.13, pp 2199 - 2202
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- Angewandte Chemie - International Edition
- Volume
- 46
- Number
- 13
- Start Page
- 2199
- End Page
- 2202
- ISSN
- 1433-7851
1521-3773
- Abstract
- (Chemical Equation Presented) Piecing together paecilomycine: The first total synthesis of paecilomycine A, a terpenoid that enhances nerve growth factor levels in certain human cells, has been achieved. Two highly stereoselective key steps in this concise route include an intermolecular Diels-Alder reaction and an intramolecular Pauson-Khand reaction (see scheme).
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Related Researcher
- Min, Sun Joon
- ERICA 공학대학 (ERICA 에너지바이오학과)