Ginsenoside-Rh2-induced mitochondrial depolarization and apoptosis are associated with reactive oxygen species-and Ca2+-mediated c-Jun NH2-terminal kinase 1 activation in HeLa cells
DC Field | Value | Language |
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dc.contributor.author | Ham, Young-Mi | - |
dc.contributor.author | Lim, Jin-Hee | - |
dc.contributor.author | Na, Hye-Kyung | - |
dc.contributor.author | Choi, Joon-Seok | - |
dc.contributor.author | Park, Byoung-Duck | - |
dc.contributor.author | Yim, Hyungshin | - |
dc.contributor.author | Lee, Seung-Ki | - |
dc.date.accessioned | 2021-06-23T21:03:11Z | - |
dc.date.available | 2021-06-23T21:03:11Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2006-12 | - |
dc.identifier.issn | 0022-3565 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/44467 | - |
dc.description.abstract | We show here that Ca2+ and reactive oxygen species (ROS) are involved in the up-regulation of c-Jun NH2-terminal kinase 1 (JNK1) activity during apoptosis induced by ginsenoside Rh2 (G-Rh2) in HeLa, MCF10A-ras, and MCF7 cells. Addition of antioxidants such as N-acetyl-L-cysteine or catalase attenuates G-Rh2-induced ROS generation, JNK1 activation, and apoptosis. The overexpression of catalase down-regulates caspase-3 and JNK1 activities. G-Rh2 treatment of cells results in mitochondrial depolarization, second mitochondrial activator of caspase release, and translocation of Bax into the mitochondria, and these events are inhibited by antioxidants. Ca2+ is also involved in mitochondrial depolarization during G-Rh2-induced apoptosis. These results suggest that ROS and Ca2+ are important signaling intermediates leading to stress- activated protein kinase/extracellular signal-regulated kinase kinase 1/JNK1 activation and depolarization of the mitochondrial membrane potential in G-Rh2-induced apoptosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS | - |
dc.title | Ginsenoside-Rh2-induced mitochondrial depolarization and apoptosis are associated with reactive oxygen species-and Ca2+-mediated c-Jun NH2-terminal kinase 1 activation in HeLa cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yim, Hyungshin | - |
dc.identifier.doi | 10.1124/jpet.106.109926 | - |
dc.identifier.scopusid | 2-s2.0-33751183316 | - |
dc.identifier.wosid | 000242048500032 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, v.319, no.3, pp.1276 - 1285 | - |
dc.relation.isPartOf | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | - |
dc.citation.title | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | - |
dc.citation.volume | 319 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1276 | - |
dc.citation.endPage | 1285 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | BCL-X-L | - |
dc.subject.keywordPlus | HUMAN LEUKEMIA-CELLS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | ROS GENERATION | - |
dc.subject.keywordPlus | JNK | - |
dc.subject.keywordPlus | BAX | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | TRANSLOCATION | - |
dc.subject.keywordPlus | INACTIVATION | - |
dc.identifier.url | https://jpet.aspetjournals.org/content/319/3/1276 | - |
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