Enhanced anti-tumor activity and alleviated hepatotoxicity of clotrimazole-loaded suppository using poloxamer-propylene glycol gel
DC Field | Value | Language |
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dc.contributor.author | Yong, Chul Soon | - |
dc.contributor.author | Xuan, Jing Ji | - |
dc.contributor.author | Paek, Seung-Hwan | - |
dc.contributor.author | Oh, Yu-Kyoung | - |
dc.contributor.author | Woo, Jong-Soo | - |
dc.contributor.author | Lee, Mann Hyung | - |
dc.contributor.author | Kim, Jung-Ae | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.date.accessioned | 2021-06-23T21:06:48Z | - |
dc.date.available | 2021-06-23T21:06:48Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2006-09 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/44682 | - |
dc.description.abstract | To develop a novel clotrimazole-loaded poloxamer-based suppository with enhanced anti-tumor activity and alleviated hepatotoxicity, the melting point of various formulations composed of P 188 and propylene glycol were investigated. The dissolution and anti-tumor activity of clotrimazole delivered by the poloxamer-based suppository was performed. Furthermore, the hepatotoxicity of clotrimazole was carried out after its rectal administration compared to oral administration in mice. The poloxamer mixtures composed of P 188 and propylene glycol were homogeneous phases. P 188 greatly affected the melting point of poloxamer mixtures. In particular, the poloxamer mixture [P 188/propylene glycol (70%/30%)] with the melting point of about 32 degrees C was a solid form at room temperature and instantly melted at physiological temperature. The ratio of P 188/propylene glycol greatly affected the dissolution rates of clotrimazole from poloxamer-based suppository. Dissolution mechanism analysis showed the dissolution rate of clotrimazole from poloxamer-based suppositories was independent of the time. The clotrimazole-loaded suppository with P 188 and propylene glycol could not irritate or damage the rectal tissues of rats and gave the improved anti-tumor activity in a dose-dependent manner at mouse. Furthermore, its rectal administration decreased the hepatotoxicity compared to oral administration. Thus, the poloxamer-based solid suppository system with clotrimazole/P 188/propylene glycol was an effective rectal dosage form for the treatment of tumors with alleviated adverse effects. (c) 2006 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Enhanced anti-tumor activity and alleviated hepatotoxicity of clotrimazole-loaded suppository using poloxamer-propylene glycol gel | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.1016/j.ijpharm.2006.05.023 | - |
dc.identifier.scopusid | 2-s2.0-33747702825 | - |
dc.identifier.wosid | 000240612200008 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.321, no.1-2, pp.56 - 61 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.citation.title | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.citation.volume | 321 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 56 | - |
dc.citation.endPage | 61 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | IN-VIVO EVALUATION | - |
dc.subject.keywordPlus | LIQUID SUPPOSITORY | - |
dc.subject.keywordPlus | ABSORPTION | - |
dc.subject.keywordPlus | BIOAVAILABILITY | - |
dc.subject.keywordPlus | ACETAMINOPHEN | - |
dc.subject.keywordPlus | ANTICANCER | - |
dc.subject.keywordPlus | POLYMERS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | SODIUM | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordAuthor | clotrimazole | - |
dc.subject.keywordAuthor | poloxamer 188 | - |
dc.subject.keywordAuthor | suppository | - |
dc.subject.keywordAuthor | melting point | - |
dc.subject.keywordAuthor | anti-tumor activity | - |
dc.subject.keywordAuthor | hepatotoxicity | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0378517306003681?via%3Dihub | - |
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