Monitoring the gene expression profiles of doxorubicin-resistant acute myelocytic leukemia cells by DNA microarray analysis
DC Field | Value | Language |
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dc.contributor.author | Song, Ju Han | - |
dc.contributor.author | Choi, Cheol Hee | - |
dc.contributor.author | Yeom, Hye-Jung | - |
dc.contributor.author | Hwang, Seung Yong | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.date.accessioned | 2021-06-23T21:39:25Z | - |
dc.date.available | 2021-06-23T21:39:25Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2006-06 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/44831 | - |
dc.description.abstract | Acquired drug-resistance phenotype is a key factor in the relapse of patients suffering hematological malignancies. In order to investigate the genes involved in drug resistance, a human leukemia cell line that is resistant to doxorubicin, an anthracycline anticancer agent (AML-2/DX100), was selected and its gene expression profile was analyzed using a cDNA microarray. A number of genes were differentially expressed in the AML-2/DX100 cells, compared with the wild type (AML-2/WT). Pro-apoptotic genes such as TNFSF7 and p21 (Cip1/Waf1) were significantly downregulated, whereas the IKBKB, PCNA, stathmin 1, MCM5, MMP-2 and MRP1 genes, which are involved in anti-apoptotic or cell cycle progression, were over-expressed. The AML-2/DX100 cells were also resistant to other anticancer drugs, including daunorubicin and camptothecin, and the expression levels of the differentially regulated genes such as STMN1, MMP-2 and CTSG, were constantly maintained. This suggests that the deregulated genes obtained from the DNA microarray analysis in a cell line model of drug resistance might contribute to the acquired drug resistance after chronic exposure. (c) 2006 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier BV | - |
dc.title | Monitoring the gene expression profiles of doxorubicin-resistant acute myelocytic leukemia cells by DNA microarray analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Seung Yong | - |
dc.identifier.doi | 10.1016/j.lfs.2005.12.054 | - |
dc.identifier.scopusid | 2-s2.0-33646687085 | - |
dc.identifier.wosid | 000238108100011 | - |
dc.identifier.bibliographicCitation | Life Sciences, v.79, no.2, pp.193 - 202 | - |
dc.relation.isPartOf | Life Sciences | - |
dc.citation.title | Life Sciences | - |
dc.citation.volume | 79 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 193 | - |
dc.citation.endPage | 202 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | MULTIDRUG-RESISTANCE | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | DRUG-RESISTANCE | - |
dc.subject.keywordPlus | P-GLYCOPROTEIN | - |
dc.subject.keywordPlus | FAS LIGAND | - |
dc.subject.keywordPlus | MATRIX-METALLOPROTEINASE | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | CDNA MICROARRAY | - |
dc.subject.keywordAuthor | leukemia | - |
dc.subject.keywordAuthor | doxorubicin | - |
dc.subject.keywordAuthor | resistance | - |
dc.subject.keywordAuthor | DNA microarray | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0024320506000269?via%3Dihub | - |
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