The metabolism and excretion of 2-methylaminoethoxycarbonyl-4,4 '-dimethoxy-5,6,5,6 '-dimethylenedioxybiphenyl-2 '-carboxylic acid (DDB-S) in rats and human
DC Field | Value | Language |
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dc.contributor.author | Yoo, Hye Hyun | - |
dc.contributor.author | Son, Junghyun | - |
dc.contributor.author | Lee, Jaeick | - |
dc.contributor.author | Kim, Nam Sun | - |
dc.contributor.author | Shin, Myungyoup | - |
dc.contributor.author | Kang, Min-Jung | - |
dc.contributor.author | Kim, Dong-Hyun | - |
dc.date.accessioned | 2021-06-23T22:40:34Z | - |
dc.date.available | 2021-06-23T22:40:34Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2006-06 | - |
dc.identifier.issn | 0951-4198 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/45417 | - |
dc.description.abstract | The metabolism and excretion of 2-methylaminoethoxycarbonyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2"-carboxylic acid (DDB-S) were investigated in both rats and humans using liquid chromatography/electrospray ion trap mass spectrometry (LC/ESI-MS/MS). In rats, DDB-S was rapidly eliminated from the body after a single 50mg/kg intravenous injection, with urine being a major excretion route. DDB-S was metabolically stable; approximately 96% of the administered dose was recovered in the form of the parent compound. Nevertheless, 12 metabolites were detected in the urine and feces collected from DDB-S-treated rats. The structural characterizations of the metabolites were elucidated from the MSn spectral analysis. Because DDB-S has a pseudo-symmetrical methylenedioxy biphenyl structure, regioselective deuterium-substituted DDB-S (d(5)-DDB-S) was used to assign the metabolic modification. The major metabolic pathways of DDB-S were identified as demethylenation of the methylenedioxy moiety, O-demethylation of the methoxy moiety and glucuronidation. In addition, N-demethylation of the methylaminoethyl group was also detected as a minor reaction. Copyright (c) 2006 John Wiley & Sons, Ltd. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | The metabolism and excretion of 2-methylaminoethoxycarbonyl-4,4 '-dimethoxy-5,6,5,6 '-dimethylenedioxybiphenyl-2 '-carboxylic acid (DDB-S) in rats and human | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Hye Hyun | - |
dc.identifier.doi | 10.1002/rcm.2549 | - |
dc.identifier.scopusid | 2-s2.0-33745791362 | - |
dc.identifier.wosid | 000238903600003 | - |
dc.identifier.bibliographicCitation | Rapid Communications in Mass Spectrometry, v.20, no.13, pp.1981 - 1988 | - |
dc.relation.isPartOf | Rapid Communications in Mass Spectrometry | - |
dc.citation.title | Rapid Communications in Mass Spectrometry | - |
dc.citation.volume | 20 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 1981 | - |
dc.citation.endPage | 1988 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Spectroscopy | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Spectroscopy | - |
dc.subject.keywordPlus | HUMAN LIVER-MICROSOMES | - |
dc.subject.keywordPlus | ASYMMETRIC HYDROGENATION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | DIMETHYL-4,4&apos | - |
dc.subject.keywordPlus | -DIMETHOXY-5,6,5&apos | - |
dc.subject.keywordPlus | ,6&apos | - |
dc.subject.keywordPlus | -DIMETHYLENEDIOXYBIPHENYL-2,2&apos | - |
dc.subject.keywordPlus | -DICARBOX YLATE | - |
dc.subject.keywordPlus | INJURY | - |
dc.identifier.url | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/rcm.2549 | - |
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