Induction of proinflammatory mediators requires activation of the TRAF, NIK, IKK and NF‐κB signal transduction pathway in astrocytes infected with Escherichia coli
DC Field | Value | Language |
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dc.contributor.author | Kim, Jung Mogg | - |
dc.contributor.author | Oh, Yukyoung | - |
dc.contributor.author | Lee, J. H. | - |
dc.contributor.author | Im, D. Y. | - |
dc.contributor.author | Kim, Yeoung-jeon | - |
dc.contributor.author | Youn, Jeehee | - |
dc.contributor.author | Lee, Chul-hoon | - |
dc.contributor.author | Son, Hyeon | - |
dc.contributor.author | Lee, Yongsung | - |
dc.contributor.author | Park, Joo-young | - |
dc.contributor.author | Choi, In Hong | - |
dc.date.accessioned | 2021-06-23T23:37:52Z | - |
dc.date.available | 2021-06-23T23:37:52Z | - |
dc.date.issued | 2005-05 | - |
dc.identifier.issn | 0009-9104 | - |
dc.identifier.issn | 1365-2249 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/45939 | - |
dc.description.abstract | Escherichia coli is associated with inflammation in the brain. To investigate whether astrocytes are involved in E. coli-induced inflammation, we assessed the levels of expression of proinflammatory mediators produced by E. coli-infected astrocytes. E. coli infection in primary human astrocytes and cell lines increased expression of the CXC chemokine IL-8/GRO-alpha, the CC chemokine MCP-1, TNF-alpha, and iNOS. E. coli infection activated p65/p50 heterodimeric NF-kappa B and concurrently decreased the signals of I kappa B alpha. Blocking the NF-kappa B signals by I kappa B alpha-superrepressor-containing retrovirus or antisense p50 oligonucleotide transfection resulted in down-regulation of expression of the proinflammatory mediators. Furthermore, superrepressors of I kappa B alpha, I kappa B kinase (IKK) or NF-kappa B inducing kinase (NIK) inhibited the up-regulated expression of the downstream target genes of NF-kappa B such as IL-8 and MCP-1, and superrepressors of TNF receptor-associated factor (TRAF)2 and TRAF5 also inhibited expression of the E. coli-induced target genes of NF-kappa B. These results indicate that proinflammatory mediators such as the CXC chemokine IL-8/GRO-alpha, the CC chemokine MCP-1, TNF-alpha, and iNOS can be expressed in E. coli-infected astrocytes via an NF-kappa B pathway, suggesting that these mediators may contribute to inflammation in the brain, including infiltration of inflammatory cells. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Induction of proinflammatory mediators requires activation of the TRAF, NIK, IKK and NF‐κB signal transduction pathway in astrocytes infected with Escherichia coli | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/j.1365-2249.2005.02804.x | - |
dc.identifier.scopusid | 2-s2.0-20444462829 | - |
dc.identifier.wosid | 000229227000007 | - |
dc.identifier.bibliographicCitation | Clinical and Experimental Immunology, v.140, no.3, pp 450 - 460 | - |
dc.citation.title | Clinical and Experimental Immunology | - |
dc.citation.volume | 140 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 450 | - |
dc.citation.endPage | 460 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | INTESTINAL EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | RECEPTOR-ASSOCIATED FACTOR | - |
dc.subject.keywordPlus | CHEMOKINE GENE-EXPRESSION | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | KINASE COMPLEX | - |
dc.subject.keywordPlus | BRAIN-ABSCESS | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordAuthor | astrocytes | - |
dc.subject.keywordAuthor | Escherichia coli | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | proinflammatory mediators | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2249.2005.02804.x | - |
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