Effects of IL-7 and dexamethasone: Induction of CD25, the high affinity IL-2 receptor, on human CD4(+) cells
DC Field | Value | Language |
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dc.contributor.author | Chung, Il Yup | - |
dc.contributor.author | Dong, Hui Fang | - |
dc.contributor.author | Zhang, Xia | - |
dc.contributor.author | Hassanein, Nahed M.A. | - |
dc.contributor.author | Howard, O.M. Zack | - |
dc.contributor.author | Oppenheim, Joost J. | - |
dc.contributor.author | Chen, Xin | - |
dc.date.accessioned | 2021-06-24T00:38:57Z | - |
dc.date.available | 2021-06-24T00:38:57Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2004-11 | - |
dc.identifier.issn | 0008-8749 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/46548 | - |
dc.description.abstract | Since we have previously shown that dexamethasone (Dex) enhances the proportion of murine Treg cells, we tested the effect of IL-7, a promoter of T cell survival, together with Dex oil human CD4(+)CD25(+) Treg cells in an in vitro setting. The results showed that IL-7 in concert with Dex markedly augmented the generation of CD4(+)CD25(+) T cells. To discern the origin of the induced CD4(+)CD25(+) T cells, MACS-purified CD4(+)CD25(-), and CD4(+)CD25(+) cells were cultured in the presence of Dex and/or IL-7 for 4 days. Although two thirds of CD4(+)CD25(-) T cells became CD4(+)CD25(+) T cells, they had no Suppressive activity. In contrast, the original CD4(+)CD25(+) T cells maintained Suppressive activity after Dex/IL-7 treatment, however, there was not a significant expansion ill their cell number. Dex and IL-7 did not induce additional Treg cells, but additively induced the expression of the activation marker CD25 by CD4(+)CD25(-) T cells. This combination may provide a novel means of priming CD4 T cells to respond to IL-2 and may prove useful in up-regulation of normal immune responses in immune deficient diseases. (c) 2005 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Academic Press | - |
dc.title | Effects of IL-7 and dexamethasone: Induction of CD25, the high affinity IL-2 receptor, on human CD4(+) cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chung, Il Yup | - |
dc.identifier.doi | 10.1016/j.cellimm.2005.01.011 | - |
dc.identifier.scopusid | 2-s2.0-19544390873 | - |
dc.identifier.wosid | 000229764300007 | - |
dc.identifier.bibliographicCitation | Cellular Immunology, v.232, no.1-2, pp.57 - 63 | - |
dc.relation.isPartOf | Cellular Immunology | - |
dc.citation.title | Cellular Immunology | - |
dc.citation.volume | 232 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 57 | - |
dc.citation.endPage | 63 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | AUTOIMMUNE-DISEASES | - |
dc.subject.keywordPlus | REGULATORY CELLS | - |
dc.subject.keywordPlus | SELF-TOLERANCE | - |
dc.subject.keywordPlus | ALPHA GENE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | GLUCOCORTICOIDS | - |
dc.subject.keywordPlus | CD4(+)CD25(+) | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | CD4(+) CD25(+) regulatory T lymphocytes | - |
dc.subject.keywordAuthor | dexamethasone | - |
dc.subject.keywordAuthor | interleukin-7 | - |
dc.subject.keywordAuthor | suppression/anergy | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0008874905000225?via%3Dihub | - |
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