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Synthesis of L-sangivamycin and toyocamycin analogues and their inhibitory activities of Ser Thr protein kinases
- Authors
- Chun, Moon Woo; Shin, Dae Hong; Song, Sun Yong; Lee, Yong Hee; Lee, Chul Hoon; Jeong, Lak Shin; Lee, Seung Ki
- Issue Date
- Dec-1998
- Publisher
- Marcel Dekker Inc.
- Citation
- Nucleosides and Nucleotides, v.18, no.4-5, pp 617 - 618
- Pages
- 2
- Indexed
- SCOPUS
- Journal Title
- Nucleosides and Nucleotides
- Volume
- 18
- Number
- 4-5
- Start Page
- 617
- End Page
- 618
- ISSN
- 0732-8311
1532-2335
- Abstract
- Novel L-sangivamycin and toyocamycin analogues were synthesized and evaluated for Cdc2 protein kinase activity. Among the compounds tested, L-xylose derivative and L-arabinose derivative exhibited potent inhibitory activity against Cdc2 protein kinase with IC50 values of 3.7 and 1.6 mu M, respectively.
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Collections - COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles
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