Thiophen urea derivatives as a new class of hepatitis C virus entry inhibitors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ryu, Hyung Chul | - |
dc.contributor.author | Windisch, Marc | - |
dc.contributor.author | Lim, Jee Woong | - |
dc.contributor.author | Choi, Inhee | - |
dc.contributor.author | Lee, Eun Kyu | - |
dc.contributor.author | Yoo, Hye Hyun | - |
dc.contributor.author | Kim, Tae Kon | - |
dc.date.accessioned | 2021-06-22T04:26:12Z | - |
dc.date.available | 2021-06-22T04:26:12Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 1475-6366 | - |
dc.identifier.issn | 1475-6374 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/484 | - |
dc.description.abstract | To develop unique small-molecule inhibitors of hepatitis C virus (HCV), thiophen urea (TU) derivatives were synthesised and screened for HCV entry inhibitory activities. Among them, seven TU compounds exhibited portent anti-viral activities against genotypes 1/2 (EC50 < 30nM) and subsequently, they were further investigated; based on the pharmacological, metabolic, pharmacokinetic, and safety profiles, J2H-1701 was selected as the optimised lead compound as an HCV entry inhibitor. J2H-1701 possesses effective multi-genotypic antiviral activity. The docking results suggested the potential interaction of J2H-1701 with the HCV E2 glycoprotein. These results suggest that J2H-1701 can be a potential candidate drug for the development of HCV entry inhibitors. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Taylor & Francis | - |
dc.title | Thiophen urea derivatives as a new class of hepatitis C virus entry inhibitors | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1080/14756366.2020.1870456 | - |
dc.identifier.scopusid | 2-s2.0-85099719142 | - |
dc.identifier.wosid | 000608281700001 | - |
dc.identifier.bibliographicCitation | Journal of Enzyme Inhibition and Medicinal Chemistry, v.36, no.1, pp 462 - 468 | - |
dc.citation.title | Journal of Enzyme Inhibition and Medicinal Chemistry | - |
dc.citation.volume | 36 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 462 | - |
dc.citation.endPage | 468 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.subject.keywordAuthor | Entry inhibitor | - |
dc.subject.keywordAuthor | hepatitis C virus | - |
dc.subject.keywordAuthor | small molecule | - |
dc.subject.keywordAuthor | thiophen urea | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/14756366.2020.1870456 | - |
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