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Total Synthesis and Biological Evaluation of Sericetin for Protection against Cisplatin-Induced Acute Kidney Injury

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dc.contributor.authorKim, Eun-Sun-
dc.contributor.authorJang, Hongjun-
dc.contributor.authorChang, Sun-Young-
dc.contributor.authorBaek, Seung-Hoon-
dc.contributor.authorBae, Ok-Nam-
dc.contributor.authorKim, Hyoungsu-
dc.date.accessioned2021-06-22T11:21:15Z-
dc.date.available2021-06-22T11:21:15Z-
dc.date.issued2018-12-
dc.identifier.issn0163-3864-
dc.identifier.issn1520-6025-
dc.identifier.urihttps://scholarworks.bwise.kr/erica/handle/2021.sw.erica/5081-
dc.description.abstractA concise synthesis of sericetin (1) was performed in four steps from readily available 3-O-benzylgalangin (4), featuring electrocyclization to produce the tricyclic core and a sequential aromatic Claisen/Cope rearrangement to incorporate the 8-prenyl group of 1. In addition, the therapeutic potential of sericetin (1), isosericetin (2), and three prenylated tetracyclic synthetic intermediates (11, 12, and 14) against cisplatin-induced nephrotoxicity using renal tubular cells were evaluated. Compound 14 showed therapeutic potential against cisplatin-induced kidney damage.-
dc.format.extent7-
dc.language영어-
dc.language.isoENG-
dc.publisherAMER CHEMICAL SOC-
dc.titleTotal Synthesis and Biological Evaluation of Sericetin for Protection against Cisplatin-Induced Acute Kidney Injury-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1021/acs.jnatprod.8b00434-
dc.identifier.scopusid2-s2.0-85058642830-
dc.identifier.wosid000454962500006-
dc.identifier.bibliographicCitationJOURNAL OF NATURAL PRODUCTS, v.81, no.12, pp 2647 - 2653-
dc.citation.titleJOURNAL OF NATURAL PRODUCTS-
dc.citation.volume81-
dc.citation.number12-
dc.citation.startPage2647-
dc.citation.endPage2653-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPlant Sciences-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryPlant Sciences-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusPRENYLATED FLAVONOIDS-
dc.subject.keywordPlusINDUCED NEPHROTOXICITY-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusMACAKURZIN C-
dc.subject.keywordPlusCELL-DEATH-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordAuthorPRENYLATED FLAVONOIDS-
dc.subject.keywordAuthorINDUCED NEPHROTOXICITY-
dc.subject.keywordAuthorOXIDATIVE STRESS-
dc.subject.keywordAuthorMACAKURZIN C-
dc.subject.keywordAuthorCELL-DEATH-
dc.subject.keywordAuthorIN-VITRO-
dc.subject.keywordAuthorINFLAMMATION-
dc.subject.keywordAuthorINHIBITION-
dc.subject.keywordAuthorMECHANISMS-
dc.subject.keywordAuthorAPOPTOSIS-
dc.identifier.urlhttps://pubs.acs.org/doi/10.1021/acs.jnatprod.8b00434-
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