Total Synthesis and Biological Evaluation of Sericetin for Protection against Cisplatin-Induced Acute Kidney Injury
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Eun-Sun | - |
dc.contributor.author | Jang, Hongjun | - |
dc.contributor.author | Chang, Sun-Young | - |
dc.contributor.author | Baek, Seung-Hoon | - |
dc.contributor.author | Bae, Ok-Nam | - |
dc.contributor.author | Kim, Hyoungsu | - |
dc.date.accessioned | 2021-06-22T11:21:15Z | - |
dc.date.available | 2021-06-22T11:21:15Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/5081 | - |
dc.description.abstract | A concise synthesis of sericetin (1) was performed in four steps from readily available 3-O-benzylgalangin (4), featuring electrocyclization to produce the tricyclic core and a sequential aromatic Claisen/Cope rearrangement to incorporate the 8-prenyl group of 1. In addition, the therapeutic potential of sericetin (1), isosericetin (2), and three prenylated tetracyclic synthetic intermediates (11, 12, and 14) against cisplatin-induced nephrotoxicity using renal tubular cells were evaluated. Compound 14 showed therapeutic potential against cisplatin-induced kidney damage. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Total Synthesis and Biological Evaluation of Sericetin for Protection against Cisplatin-Induced Acute Kidney Injury | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, Ok-Nam | - |
dc.identifier.doi | 10.1021/acs.jnatprod.8b00434 | - |
dc.identifier.scopusid | 2-s2.0-85058642830 | - |
dc.identifier.wosid | 000454962500006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NATURAL PRODUCTS, v.81, no.12, pp.2647 - 2653 | - |
dc.relation.isPartOf | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.title | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.volume | 81 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2647 | - |
dc.citation.endPage | 2653 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | PRENYLATED FLAVONOIDS | - |
dc.subject.keywordPlus | INDUCED NEPHROTOXICITY | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | MACAKURZIN C | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordAuthor | PRENYLATED FLAVONOIDS | - |
dc.subject.keywordAuthor | INDUCED NEPHROTOXICITY | - |
dc.subject.keywordAuthor | OXIDATIVE STRESS | - |
dc.subject.keywordAuthor | MACAKURZIN C | - |
dc.subject.keywordAuthor | CELL-DEATH | - |
dc.subject.keywordAuthor | IN-VITRO | - |
dc.subject.keywordAuthor | INFLAMMATION | - |
dc.subject.keywordAuthor | INHIBITION | - |
dc.subject.keywordAuthor | MECHANISMS | - |
dc.subject.keywordAuthor | APOPTOSIS | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acs.jnatprod.8b00434 | - |
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