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Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy
- Authors
- Das, Manabendra; Du, Yang; Mortensen, Jonas S.; Hariharan, Parameswaran; Lee, Hyun Sung; Byrne, Bernadette; Loland, Claus J.; Guan, Lan; Kobilka, Brian K.; Chae, Pil Seok
- Issue Date
- Oct-2018
- Publisher
- John Wiley & Sons Ltd.
- Keywords
- detergent design; detergent faciality; amphiphiles; protein stabilization; protein structures
- Citation
- ChemBioChem, v.19, no.20, pp.2225 - 2232
- Indexed
- SCIE
SCOPUS
- Journal Title
- ChemBioChem
- Volume
- 19
- Number
- 20
- Start Page
- 2225
- End Page
- 2232
- ISSN
- 1439-4227
- Abstract
- A new family of tandem facial glucosides/maltosides (TFGs/TFMs) for membrane protein manipulation was prepared. The best detergent varied depending on the hydrophobic thickness of the target protein, but ether-based TFMs (TFM-C0E, TFM-C3E, and TFM-C5E) were notable for their ability to confer higher membrane protein stability than the previously developed amide-based TFA-1 (P.S. Chae, K. Gotfryd, J. Pacyna, L.J.W. Miercke, S.G.F. Rasmussen, R.A. Robbins, R.R. Rana, C.J. Loland, B. Kobilka, R. Stroud, B. Byrne, U. Gether, S.H. Gellman, ). Thus, this study not only introduces novel agents with the potential to be used in membrane protein research but also highlights the importance of both the hydrophobic length and linker functionality of the detergent in stabilizing membrane proteins.
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Related Researcher
- Chae, Pil Seok
- ERICA 공학대학 (DEPARTMENT OF BIONANO ENGINEERING)