Antitumor activity of BJ-1207, a 6-amino-2,4,5-trimethylpyridin-3-ol derivative, in human lung cancer
DC Field | Value | Language |
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dc.contributor.author | Gautam, Jaya | - |
dc.contributor.author | Banskota, Suhrid | - |
dc.contributor.author | Chaudhary, Prakash | - |
dc.contributor.author | Dahal, Sadan | - |
dc.contributor.author | Kim, Dong-Guk | - |
dc.contributor.author | Kang, Han-eol | - |
dc.contributor.author | Lee, Iyn-Hyang | - |
dc.contributor.author | Nam, Tae-Gyu | - |
dc.contributor.author | Jeong, Byeong-Seon | - |
dc.contributor.author | Kim, Jung-Ae | - |
dc.date.accessioned | 2021-06-22T11:22:55Z | - |
dc.date.available | 2021-06-22T11:22:55Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 0009-2797 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/5251 | - |
dc.description.abstract | Enhanced expression of NADPH oxidase (NOX) and the subsequent production of reactive oxygen species (ROS) are associated with lung cancer. In the present study, fifty 6-amino-2,4,5-trimethylpyridin-3-ol derivatives were screened for anticancer activity by targeting NOX2-derived ROS. The compounds suppressed ROS production and decreased cancer cell viability (R-2= 0.79). Among the derivatives, the compound coded BJ-1207, which contained a 4-(hydroxydiphenylmethyl) piperidine moiety, exhibited the most effective anticancer activity against A549 lung cancer cell line and eight other cancer cell lines, including H1299, MCF-7, MDA-MB-231, HT29, SW620, Mia PaCa-2, PANC-1, and U937. BJ-1207 also showed significantly lower inhibitory effects on kinase insert domain receptor (KDR) and c-KIT tyrosine kinase but higher inhibitory activity on NOX than those of sunitinib, a multi-receptor tyrosine kinase (RTK) inhibitor. In addition, BJ-1207-induced inhibition of RTK-downstream signaling pathways, such as ROS production, and expression of target genes, such as stem cell factor and transforming growth factor-alpha, were similar to those induced by sunitinib. In the xenograft chick tumor model, BJ-1207 inhibited lung tumor growth to a similar or much greater extent than that of sunitinib or cisplatin, respectively. Overall, the present study showed that BJ-1207, a vitamin B-6-derived 2,4,5-trimethylpyridin-3-ol compound with azacyclonol moiety at C (6)-position of the pyridine ring, inhibited NOX activity and that it is a promising lead compound for developing anticancer drugs against lung cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | Antitumor activity of BJ-1207, a 6-amino-2,4,5-trimethylpyridin-3-ol derivative, in human lung cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Nam, Tae-Gyu | - |
dc.identifier.doi | 10.1016/j.cbi.2018.08.007 | - |
dc.identifier.scopusid | 2-s2.0-85051652320 | - |
dc.identifier.wosid | 000444012500001 | - |
dc.identifier.bibliographicCitation | CHEMICO-BIOLOGICAL INTERACTIONS, v.294, pp.1 - 8 | - |
dc.relation.isPartOf | CHEMICO-BIOLOGICAL INTERACTIONS | - |
dc.citation.title | CHEMICO-BIOLOGICAL INTERACTIONS | - |
dc.citation.volume | 294 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | NADPH OXIDASE | - |
dc.subject.keywordPlus | TYROSINE KINASE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | FREE-RADICALS | - |
dc.subject.keywordPlus | HUMAN TUMORS | - |
dc.subject.keywordPlus | CELL LINES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordAuthor | Aminopyridin-3-ols | - |
dc.subject.keywordAuthor | Non-small cell lung cancer | - |
dc.subject.keywordAuthor | NADPH oxidase | - |
dc.subject.keywordAuthor | Stem cell factor | - |
dc.subject.keywordAuthor | Transforming growth factor-alpha | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0009279718306641?via%3Dihub | - |
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