Ceria Nanoparticle Systems for Selective Scavenging of Mitochondrial, Intracellular, and Extracellular Reactive Oxygen Species in Parkinson's Disease
- Authors
- Kwon, Hyek Jin; Kim, Dokyoon; Seo, Kyungho; Kim, Young Geon; Han, Sang Ihn; Kang, Taegyu; Soh, Min; Hyeon, Taeghwan
- Issue Date
- Jul-2018
- Publisher
- John Wiley & Sons Ltd.
- Keywords
- ceria; mitochondria; nanoparticles; Parkinson' s disease; reactive oxygen species
- Citation
- Angewandte Chemie - International Edition, v.57, no.30, pp.9408 - 9412
- Indexed
- SCIE
SCOPUS
- Journal Title
- Angewandte Chemie - International Edition
- Volume
- 57
- Number
- 30
- Start Page
- 9408
- End Page
- 9412
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/5759
- DOI
- 10.1002/anie.201805052
- ISSN
- 1433-7851
- Abstract
- Oxidative stress induced by reactive oxygen species (ROS) is one of the critical factors that involves in the pathogenesis and progression of many diseases. However, lack of proper techniques to scavenge ROS depending on their cellular localization limits a thorough understanding of the pathological effects of ROS. Here, we demonstrate the selective scavenging of mitochondrial, intracellular, and extracellular ROS using three different types of ceria nanoparticles (NPs), and its application to treat Parkinson's disease (PD). Our data show that scavenging intracellular or mitochondrial ROS inhibits the microglial activation and lipid peroxidation, while protecting the tyrosine hydroxylase (TH) in the striata of PD model mice. These results indicate the essential roles of intracellular and mitochondrial ROS in the progression of PD. We anticipate that our ceria NP systems will serve as a useful tool for elucidating the functions of various ROS in diseases.
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Collections - COLLEGE OF ENGINEERING SCIENCES > DEPARTMENT OF BIONANO ENGINEERING > 1. Journal Articles
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