Isolation of primitive mouse extraembryonic endoderm (pXEN) stem cell lines
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhong, Yixiang | - |
dc.contributor.author | Choi, Taewoong | - |
dc.contributor.author | Kim, Minjae | - |
dc.contributor.author | Jung, Kyoung Hwa | - |
dc.contributor.author | Chai, Young Gyu | - |
dc.contributor.author | Binas, Bert | - |
dc.date.accessioned | 2021-06-22T11:42:51Z | - |
dc.date.available | 2021-06-22T11:42:51Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2018-07 | - |
dc.identifier.issn | 1873-5061 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/5795 | - |
dc.description.abstract | Mouse blastocysts contain the committed precursors of the extraembryonic endoderm (ExEn), which express the key transcription factor Oct4, depend on LIF/LIF-like factor-driven Jak/Stat signaling, and initially exhibit lineage plasticity. Previously described rat blastocyst-derived ExEn precursor-like cell lines (XENP cells/HypoSCs) also show these features, but equivalent mouse blastocyst-derived cell lines are lacking. We now present mouse blastocyst-derived cell lines, named primitive XEN (pXEN) cells, which share these and additional characteristics with the XENP cells/HypoSCs, but not with previously known mouse blastocyst-derived XEN cell lines. Otherwise, pXEN cells are highly similar to XEN cells by morphology, lineage-intrinsic differentiation potential, and multi-gene expression profile, although the pXEN cell profile correlates better with the blastocyst stage. Finally, we show that pXEN cells easily convert into XEN-like cells but not vice versa. The findings indicate that (i) pXEN cells are more representative than XEN cells of the blastocyst stage; (ii) mouse pXEN, rather than XEN, cells are homologs of rat XENP cells/HypoSCs, which we propose to call rat pXEN cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Isolation of primitive mouse extraembryonic endoderm (pXEN) stem cell lines | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Binas, Bert | - |
dc.identifier.doi | 10.1016/j.scr.2018.05.008 | - |
dc.identifier.scopusid | 2-s2.0-85047456600 | - |
dc.identifier.wosid | 000438786600013 | - |
dc.identifier.bibliographicCitation | STEM CELL RESEARCH, v.30, pp.100 - 112 | - |
dc.relation.isPartOf | STEM CELL RESEARCH | - |
dc.citation.title | STEM CELL RESEARCH | - |
dc.citation.volume | 30 | - |
dc.citation.startPage | 100 | - |
dc.citation.endPage | 112 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | CULTURE-CONDITIONS SUPPORT | - |
dc.subject.keywordPlus | SELF-RENEWAL | - |
dc.subject.keywordPlus | XEN CELLS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | VISCERAL ENDODERM | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | BLASTOCYST | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | EMBRYOS | - |
dc.subject.keywordPlus | OCT4 | - |
dc.subject.keywordAuthor | Stem cells | - |
dc.subject.keywordAuthor | Blastocyst | - |
dc.subject.keywordAuthor | Mice | - |
dc.subject.keywordAuthor | Rats | - |
dc.subject.keywordAuthor | Extraembryonic endoderm | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1873506118301260?via%3Dihub | - |
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