PEGylated nanographene-mediated metallic nanoparticle clusters for surface enhanced Raman scattering-based biosensing
DC Field | Value | Language |
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dc.contributor.author | Ali, Ahmed | - |
dc.contributor.author | Hwang, Eun Young | - |
dc.contributor.author | Choo, Jaebum | - |
dc.contributor.author | Lim, Dong Woo | - |
dc.date.accessioned | 2021-06-22T11:43:25Z | - |
dc.date.available | 2021-06-22T11:43:25Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 0003-2654 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/5853 | - |
dc.description.abstract | Surface-enhanced Raman scattering (SERS) is an optical spectroscopy technique that can detect a variety of analytes with high sensitivity and selectivity without any labels. Controlled clustering of metallic nanoparticles to prepare a new class of SERS nanotags is crucial for the ultra-sensitive detection of specific biological and chemical moieties because increased plasmonic hotspot junctions produce a greatly enhanced SERS signal. We report herein that controlled clustering of Au nanoparticles (AuNPs) was mediated by PEGylated nano-sized graphene (PNG) and that the PNG-induced AuNP clusters (PNG-AuNPCs) were highly sensitive SERS nanotags with colloidal stability for SERS-based biosensing. The AuNPs labeled with 4-mercaptopyridine as a Raman reporter were surface-modified with 1-aminomethylpyrene for the introduction of hydrophobic moieties, and were non-covalently complexed with PNG via p-p stacking and van der Waals forces. It resulted in the formation of PNG-AuNPCs that increased SERS intensity with an enhancement factor of 1.34 x 1011. The PNG induced a high degree of AuNP clustering by enhancing the non-covalent interactions between them, resulting in increased hotspot junctions at highly localized plasmonic centers. Furthermore, to show that the PNG-AuNPCs would serve as stable, reproducible, and highly sensitive SERS nanotags for biosensing, we formed sandwich-type immunocomplexes composed of the PNG-AuNPCs, immunoglobulin G (IgG) as the antigen, and magnetic beads. We found a linear relationship between SERS intensity and IgG concentration, with a limit of detection lower than 31.0 fM for IgG detection. Thus, the PNG-AuNPCs could be useful as SERS nanotags for highly sensitive SERS-based biosensing applications. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | PEGylated nanographene-mediated metallic nanoparticle clusters for surface enhanced Raman scattering-based biosensing | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Dong Woo | - |
dc.identifier.doi | 10.1039/c8an00329g | - |
dc.identifier.scopusid | 2-s2.0-85047757472 | - |
dc.identifier.wosid | 000433509800018 | - |
dc.identifier.bibliographicCitation | ANALYST, v.143, no.11, pp.2604 - 2615 | - |
dc.relation.isPartOf | ANALYST | - |
dc.citation.title | ANALYST | - |
dc.citation.volume | 143 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2604 | - |
dc.citation.endPage | 2615 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.subject.keywordPlus | REDUCED GRAPHENE OXIDE | - |
dc.subject.keywordPlus | SILVER NANOPARTICLE | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | OPTICAL NANOPROBES | - |
dc.subject.keywordPlus | SERS DETECTION | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | NANO-GRAPHENE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordPlus | SPECTROSCOPY | - |
dc.identifier.url | https://pubs.rsc.org/en/content/articlelanding/2018/AN/C8AN00329G | - |
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