miR-25 Tough Decoy Enhances Cardiac Function in Heart Failure
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Dongtak | - |
dc.contributor.author | Yoo, Jimeen | - |
dc.contributor.author | Lee, Philyoung | - |
dc.contributor.author | Kepreotis, Sacha, V | - |
dc.contributor.author | Lee, Ahyoung | - |
dc.contributor.author | Wahlquist, Christine | - |
dc.contributor.author | Brown, Brian D. | - |
dc.contributor.author | Kho, Changwon | - |
dc.contributor.author | Mercola, Mark | - |
dc.contributor.author | Hajjar, Roger J. | - |
dc.date.accessioned | 2021-06-22T12:03:11Z | - |
dc.date.available | 2021-06-22T12:03:11Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2018-03 | - |
dc.identifier.issn | 1525-0016 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/6408 | - |
dc.description.abstract | MicroRNAs are promising therapeutic targets, because their inhibition has the potential to normalize gene expression in diseased states. Recently, our group found that miR-25 is a key SERCA2a regulating microRNA, and we showed that multiple injections of antagomirs against miR-25 enhance cardiac contractility and function through SERCA2a restoration in a murine heart failure model. However, for clinical application, a more stable suppressor of miR-25 would be desirable. Tough Decoy (TuD) inhibitors are emerging as a highly effective method for microRNA inhibition due to their resistance to endonucleolytic degradation, high miRNA binding affinity, and efficient delivery. We generated a miR-25 TuD inhibitor and subcloned it into a cardiotropic AAV9 vector to evaluate its efficacy. The AAV9 TuD showed selective inhibition of miR-25 in vitro cardiornyoblast culture. In vivo, AAV9-miR-25 TuD delivered to the murine pressure-overload heart failure model selectively decreased expression of miR-25, increased levels of SERCA2a protein, and ameliorated cardiac dysfunction and fibrosis. Our data indicate that miR-25 TuD is an effective long-term suppressor of miR-25 and a promising therapeutic candidate to treat heart failure. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.title | miR-25 Tough Decoy Enhances Cardiac Function in Heart Failure | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeong, Dongtak | - |
dc.identifier.doi | 10.1016/j.ymthe.2017.11.014 | - |
dc.identifier.scopusid | 2-s2.0-85038957372 | - |
dc.identifier.wosid | 000427911800010 | - |
dc.identifier.bibliographicCitation | MOLECULAR THERAPY, v.26, no.3, pp.718 - 729 | - |
dc.relation.isPartOf | MOLECULAR THERAPY | - |
dc.citation.title | MOLECULAR THERAPY | - |
dc.citation.volume | 26 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 718 | - |
dc.citation.endPage | 729 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | LONG-TERM | - |
dc.subject.keywordPlus | MICRORNAS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CONTRACTILITY | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordAuthor | AAV9 | - |
dc.subject.keywordAuthor | calcium signaling | - |
dc.subject.keywordAuthor | gene therapy | - |
dc.subject.keywordAuthor | heart failure | - |
dc.subject.keywordAuthor | miR-25 | - |
dc.subject.keywordAuthor | miRNA | - |
dc.subject.keywordAuthor | SERCA2a | - |
dc.subject.keywordAuthor | Tough Decoy | - |
dc.subject.keywordAuthor | TuD | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1525001617305737?via%3Dihub | - |
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