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Formulation of novel dry powder inhalation for fluticasone propionate and salmeterol xinafoate with capsule-based device

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dc.contributor.authorKim, Kyeong Soo-
dc.contributor.authorKim, Jeong Hyun-
dc.contributor.authorJin, Sung Giu-
dc.contributor.authorKim, Dong Wuk-
dc.contributor.authorKim, Jong Oh-
dc.contributor.authorYong, Chul Soon-
dc.contributor.authorYoun, Yu Seok-
dc.contributor.authorOh, Kyung Taek-
dc.contributor.authorWoo, Jong Soo-
dc.contributor.authorChoi, Han-Gon-
dc.date.accessioned2021-06-22T13:03:35Z-
dc.date.available2021-06-22T13:03:35Z-
dc.date.created2021-01-21-
dc.date.issued2018-01-
dc.identifier.issn1083-7450-
dc.identifier.urihttps://scholarworks.bwise.kr/erica/handle/2021.sw.erica/7984-
dc.description.abstractThe aim of this study was to develop a novel fluticasone propionate (FP) and salmeterol xinafoate (SX)-loaded dry powder inhaler (DPI) system, which was composed of powder formulation and performance. The air flow resistances were determined with various types of DPI device, showing that the modified RS01 device gave the specific resistance similar to the commercial DPI device. The particle properties of FP, SX, and inhalation grade lactose particles, such as particle size, size distribution, and fine content, were assessed. Subsequently, the aerodynamic behaviors of the DPI powder formulations were evaluated by the in vitro deposition of drugs in the DPI products using Andersen cascade impactor. Amongst the DPI powder formulations tested, the formulation composed of FP, SX, Respitose((R)) SV003, Respitose((R)) SV010, and Respitose((R)) ML006 at the weight ratio of 0.5/0.145/19/19/2 gave depositions, emitted dose, fine particle dose, fine particle fraction, and mass median aerodynamic diameter of drugs similar to the commercial product, suggesting that they had similar aerodynamic behaviors. Furthermore, it gave excellent content uniformity. Thus, this DPI using the modified RS01 device would be recommended as a candidate for FP and SX-loaded pharmaceutical DPI products.-
dc.language영어-
dc.language.isoen-
dc.publisherTAYLOR & FRANCIS LTD-
dc.titleFormulation of novel dry powder inhalation for fluticasone propionate and salmeterol xinafoate with capsule-based device-
dc.typeArticle-
dc.contributor.affiliatedAuthorChoi, Han-Gon-
dc.identifier.doi10.1080/10837450.2017.1342656-
dc.identifier.scopusid2-s2.0-85021954732-
dc.identifier.wosid000419986600005-
dc.identifier.bibliographicCitationPHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, v.23, no.2, pp.158 - 166-
dc.relation.isPartOfPHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY-
dc.citation.titlePHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY-
dc.citation.volume23-
dc.citation.number2-
dc.citation.startPage158-
dc.citation.endPage166-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusSALBUTAMOL SULFATE-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusPARTICLE-SIZE-
dc.subject.keywordPlusAEROSOL PERFORMANCE-
dc.subject.keywordPlusCARRIER PARTICLES-
dc.subject.keywordPlusMULTIDOSE INHALER-
dc.subject.keywordPlusLACTOSE-
dc.subject.keywordPlusDESIGN-
dc.subject.keywordPlusCOMBINATION-
dc.subject.keywordPlusDISPERSION-
dc.subject.keywordAuthorDry powder inhaler-
dc.subject.keywordAuthorfluticasone propionate-
dc.subject.keywordAuthorsalmeterol xinafoate-
dc.subject.keywordAuthorlactose-
dc.subject.keywordAuthorpowder formulation-
dc.subject.keywordAuthordeposition-
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.1080/10837450.2017.1342656-
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