ESRRA (estrogen-related receptor alpha) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense
DC Field | Value | Language |
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dc.contributor.author | Kim, Soo Yeon | - |
dc.contributor.author | Yang, Chul-Su | - |
dc.contributor.author | Lee, Hye-Mi | - |
dc.contributor.author | Kim, Jin Kyung | - |
dc.contributor.author | Kim, Yi-Sak | - |
dc.contributor.author | Kim, Ye-Ram | - |
dc.contributor.author | Kim, Jae-Sung | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.contributor.author | Yuk, Jae-Min | - |
dc.contributor.author | Dufour, Catherine Rosa | - |
dc.contributor.author | Lee, Sang-Hee | - |
dc.contributor.author | Kim, Jin-Man | - |
dc.contributor.author | Choi, Hueng-Sik | - |
dc.contributor.author | Giguere, Vincent | - |
dc.contributor.author | Jo, Eun-Kyeong | - |
dc.date.accessioned | 2021-06-22T13:04:29Z | - |
dc.date.available | 2021-06-22T13:04:29Z | - |
dc.date.issued | 2018-00 | - |
dc.identifier.issn | 1554-8627 | - |
dc.identifier.issn | 1554-8635 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/8040 | - |
dc.description.abstract | The orphan nuclear receptor ESRRA (estrogen-related receptor alpha) is a key regulator of energy homeostasis and mitochondrial function. Macroautophagy/autophagy, an intracellular degradation process, is a critical innate effector against intracellular microbes. Here, we demonstrate that ESRRA is required for the activation of autophagy to promote innate antimicrobial defense against mycobacterial infection. AMP-activated protein kinase pathway and SIRT1 (sirtuin 1) activation led to induction of ESRRA, which is essential for autophagosome formation, in bone marrow-derived macrophages. ESRRA enhanced the transcriptional activation of numerous autophagy-related (Atg) genes containing ERR response elements in their promoter regions. Furthermore, ESRRA, operating in a feed-forward loop with SIRT1, was required for autophagy activation through deacetylation of ATG5, BECN1, and ATG7. Importantly, ESRRA deficiency resulted in a decrease of phagosomal maturation and antimicrobial responses against mycobacterial infection. Thus, we identify ESRRA as a critical activator of autophagy via both transcriptional and post-translational control to promote antimicrobial host responses. | - |
dc.format.extent | 17 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Landes Bioscience | - |
dc.title | ESRRA (estrogen-related receptor alpha) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1080/15548627.2017.1339001 | - |
dc.identifier.scopusid | 2-s2.0-85028859411 | - |
dc.identifier.wosid | 000427049900011 | - |
dc.identifier.bibliographicCitation | Autophagy, v.14, no.1, pp 152 - 168 | - |
dc.citation.title | Autophagy | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 152 | - |
dc.citation.endPage | 168 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | ERR-ALPHA | - |
dc.subject.keywordPlus | METABOLIC REGULATOR | - |
dc.subject.keywordPlus | DIRECTED THERAPIES | - |
dc.subject.keywordPlus | SIRT1 DEACETYLASE | - |
dc.subject.keywordPlus | NUCLEAR RECEPTORS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ORPHAN | - |
dc.subject.keywordPlus | FOXO | - |
dc.subject.keywordAuthor | autophagy-related genes | - |
dc.subject.keywordAuthor | estrogen-related receptor alpha | - |
dc.subject.keywordAuthor | innate antimicrobial defense | - |
dc.subject.keywordAuthor | Mycobacterium tuberculosis | - |
dc.subject.keywordAuthor | post-translational modifications | - |
dc.subject.keywordAuthor | sirtuin 1 | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/15548627.2017.1339001 | - |
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