Fermented Red Ginseng Alleviates Cyclophosphamide-Induced Immunosuppression and 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis in Mice by Regulating Macrophage Activation and T Cell Differentiation
DC Field | Value | Language |
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dc.contributor.author | Kim, Jeon-Kyung | - |
dc.contributor.author | Kim, Jae-Young | - |
dc.contributor.author | Jang, Se-Eun | - |
dc.contributor.author | Choi, Min-Sun | - |
dc.contributor.author | Jang, Hyo-Min | - |
dc.contributor.author | Yoo, Hae-Hyun | - |
dc.contributor.author | Kim, Dong-Hyun | - |
dc.date.accessioned | 2021-06-22T13:04:36Z | - |
dc.date.available | 2021-06-22T13:04:36Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 0192-415X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/8047 | - |
dc.description.abstract | A variety of products have been developed with red ginseng (RG, the steamed roots of Panax ginseng Meyer). To clarify the immunomodulating effects of water-extracted RG (wRG), 50% ethanol-extracted RG (eRG), enzyme-treated eRG (ERG) and probioticfermented eRG (FRG), we examined their immunopotentiating and immunosuppressive effects in mice with cyclophosphamide (CP)-induced immunosuppression (CI) or 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis (TC). Oral administration of RG in CI mice significantly increased blood IFN-gamma levels. Treatment with RG also increased the tumoricidal effects of CI mouse splenic cytotoxic T (Tc) and NK cells against YAC-1 cells. Treatment with RGs, in particular FRG and wRG, significantly increased Th1 cell differentiation. Treatment with RG except wRG increased Treg cell differentiation. However, wRG alone increased IL-6 and IL-17 expression in the colon of CI mice. Furthermore, RG alleviated colitis in TC mice. FRG most potently suppressed TNBS-induced colon shortening, NF-kappa B activation and TNF-alpha and IL-17 expression and increased IL-10 expression. RGs inhibited TNF-alpha expression and increased IL-10 expression in lipopolysaccharide-stimulated primary macrophages in vitro while the differentiation of splenic T cells into type 1 T (Th1) and regulatory T (Treg) cells was increased by FRG in vitro. In conclusion, FRG can alleviate immunosuppression and inflammation by inhibiting macrophage activation and regulating Thl and Treg cell differentiation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | World Scientific Publishing Co | - |
dc.title | Fermented Red Ginseng Alleviates Cyclophosphamide-Induced Immunosuppression and 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis in Mice by Regulating Macrophage Activation and T Cell Differentiation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Hae-Hyun | - |
dc.identifier.doi | 10.1142/S0192415X18500945 | - |
dc.identifier.scopusid | 2-s2.0-85058038166 | - |
dc.identifier.wosid | 000455230200010 | - |
dc.identifier.bibliographicCitation | American Journal of Chinese Medicine, v.46, no.8, pp.1879 - 1897 | - |
dc.relation.isPartOf | American Journal of Chinese Medicine | - |
dc.citation.title | American Journal of Chinese Medicine | - |
dc.citation.volume | 46 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1879 | - |
dc.citation.endPage | 1897 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | PANAX-GINSENG | - |
dc.subject.keywordPlus | COMPOUND K | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ANTITUMOR | - |
dc.subject.keywordPlus | INHIBIT | - |
dc.subject.keywordPlus | DRIVE | - |
dc.subject.keywordPlus | RG1 | - |
dc.subject.keywordAuthor | Immunomodulation | - |
dc.subject.keywordAuthor | Immunosuppression | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Probiotic-Fermented Red Ginseng | - |
dc.identifier.url | https://www.worldscientific.com/doi/abs/10.1142/S0192415X18500945 | - |
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