Engineering oxygen nanobubbles for the effective reversal of hypoxia
DC Field | Value | Language |
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dc.contributor.author | Khan, Muhammad Saad | - |
dc.contributor.author | Hwang, Jangsun | - |
dc.contributor.author | Seo, Youngmin | - |
dc.contributor.author | Shin, Kyusoon | - |
dc.contributor.author | Lee, Kyungwoo | - |
dc.contributor.author | Park, Chanhwi | - |
dc.contributor.author | Choi, Yonghyun | - |
dc.contributor.author | Hong, Jong Wook | - |
dc.contributor.author | Choi, Jonghoon | - |
dc.date.accessioned | 2021-06-22T13:04:40Z | - |
dc.date.available | 2021-06-22T13:04:40Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 2169-1401 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/8050 | - |
dc.description.abstract | Hypoxia, which results from an inadequate supply of oxygen, is a major cause of concern in cancer therapy as it is associated with a reduction in the effectiveness of chemotherapy and radiotherapy in cancer treatment. Overexpression and stabilization of hypoxia-inducible factor 1 alpha (HIF-1 alpha) protein in tumours, due to hypoxia, results in poor prognosis and increased patient mortality. To increase oxygen tension in hypoxic areas, micro- and nanobubbles have been investigated by various researchers. In the present research, lipid-shelled oxygen nanobubbles (ONBs) were synthesized through a sonication method to reverse hypoxic conditions created in a custom-made hypoxic chamber. Release of oxygen gas from ONBs in deoxygenated water was evaluated by measuring dissolved oxygen. Hypoxic conditions were evaluated by performing in vitro experiments on MDA-MB231 breast cancer cells through the expression of HIF-1 alpha and the fluorescence of image-iT (TM) hypoxia reagent. The results indicated the degradation of HIF-1 alpha after the introduction of ONBs. We propose that ONBs are successful in reversing hypoxia, downregulating HIF-1 alpha, and improving cellular conditions, leading to further medical applications. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Engineering oxygen nanobubbles for the effective reversal of hypoxia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Jong Wook | - |
dc.identifier.doi | 10.1080/21691401.2018.1492420 | - |
dc.identifier.scopusid | 2-s2.0-85050555526 | - |
dc.identifier.wosid | 000460141900031 | - |
dc.identifier.bibliographicCitation | ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, v.46, no.3, pp.S318 - S327 | - |
dc.relation.isPartOf | ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | - |
dc.citation.title | ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | - |
dc.citation.volume | 46 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | S318 | - |
dc.citation.endPage | S327 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | INDUCIBLE FACTOR-1 | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | MICROBUBBLES | - |
dc.subject.keywordPlus | ULTRASOUND | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Hypoxia | - |
dc.subject.keywordAuthor | oxygen nanobubbles | - |
dc.subject.keywordAuthor | HIF-1 alpha | - |
dc.subject.keywordAuthor | MDA-MB231 | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/21691401.2018.1492420 | - |
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