Novel revaprazan-loaded gelatin microsphere with enhanced drug solubility and oral bioavailability
- Authors
- Kim, Jung Suk; Park, Jong Hyuck; Jeong, Sung Chan; Kim, Dong Shik; Yousaf, Abid Mehmood; Din, Fakhar Ud; Kim, Jong Oh; Yong, Chul Soon; Youn, Yu Seok; Oh, Kyung Taek; Jin, Sung Giu; Choi, Han-Gon
- Issue Date
- Oct-2018
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Gelatine microsphere; revaprazan; spray-drying; drug solubility; oral bioavailability
- Citation
- JOURNAL OF MICROENCAPSULATION, v.35, no.5, pp.421 - 427
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF MICROENCAPSULATION
- Volume
- 35
- Number
- 5
- Start Page
- 421
- End Page
- 427
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/8051
- DOI
- 10.1080/02652048.2018.1515997
- ISSN
- 0265-2048
- Abstract
- To develop a novel revaprazan-loaded gelatine microsphere with enhanced solubility and oral bioavailability, numerous gelatine microspheres were prepared using a spray-drying technique. The impact of gelatine amount on drug solubility in the gelatine microspheres was investigated. The physicochemical properties of the selected gelatine microsphere, such as shape, particle size and crystallinity, were evaluated. Moreover, its dissolution and pharmacokinetics in rats were assessed in comparison with revaprazan powder. Amongst the gelatine microspheres tested, the gelatine microsphere consisting of revaprazan and gelatine (1:2, w/w), which gave about 150-fold increased solubility, had the most enhanced drug solubility. It provided a spherical shape, amorphous drug and reduced particle size. Furthermore, it gave a higher dissolution rate and plasma concentration than did revaprazan powder. Particularly, it gave about 2.3-fold improved oral bioavailability in comparison with revaprazan powder. Therefore, this novel gelatine microsphere system is recommended as an oral pharmaceutical product of poorly water-soluble revaprazan.
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