How Z-DNA/RNA binding proteins shape homeostasis, inflammation, and immunity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Chun | - |
dc.date.accessioned | 2021-06-22T05:59:34Z | - |
dc.date.available | 2021-06-22T05:59:34Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/859 | - |
dc.description.abstract | The right-handed double-helical structure of DNA (B-DNA), which follows the Watson-Crick model, is the canonical form of DNA existing in normal physiological settings. Even though an alternative left-handed structure of DNA (Z-DNA) was discovered in the late 1970s, Z-form nucleic acid has not received much attention from biologists, because it is extremely unstable under physiological conditions, has an ill-defined mechanism of its formation, and has obscure biological functions. The debate about the physiological relevance of Z-DNA was settled only after a class of proteins was found to potentially recognize the Z-form architecture of DNA. Interestingly, these Z-DNA binding proteins can bind not only the left-handed form of DNA but also the equivalent structure of RNA (Z-RNA). The Z-DNA/RNA binding proteins present from viruses to humans function as important regulators of biological processes. In particular, the proteins ADAR1 and ZBP1 are currently being extensively re-evaluated in the field to understand potential roles of the noncanonical Z-conformation of nucleic acids in host immune responses and human disease. Despite a growing body of evidence supporting the biological importance of Z-DNA/RNA, there remain many unanswered principal questions, such as when Z-form nucleic acids arise and how they signal to downstream pathways. Understanding Z-DNA/RNA and the sensors in different pathophysiological conditions will widen our view on the regulation of immune responses and open a new door of opportunity to develop novel types of immunomodulatory therapeutic possibilities. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.title | How Z-DNA/RNA binding proteins shape homeostasis, inflammation, and immunity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chun | - |
dc.identifier.doi | 10.5483/BMBRep.2020.53.9.141 | - |
dc.identifier.scopusid | 2-s2.0-85091588400 | - |
dc.identifier.wosid | 000575861300002 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.53, no.9, pp.453 - 457 | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 53 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 453 | - |
dc.citation.endPage | 457 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART002627612 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | Z-DNA-BINDING | - |
dc.subject.keywordPlus | EDITING ENZYME ADAR1 | - |
dc.subject.keywordPlus | Z-ALPHA DOMAIN | - |
dc.subject.keywordPlus | DSRNA ADENOSINE-DEAMINASE | - |
dc.subject.keywordPlus | HANDED Z-DNA | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | ENDOGENOUS RNA | - |
dc.subject.keywordPlus | EXPORT SIGNAL | - |
dc.subject.keywordPlus | CYTOSOLIC DNA | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordAuthor | ADAR1 | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Necroptosis | - |
dc.subject.keywordAuthor | ZBP1 | - |
dc.subject.keywordAuthor | Z-DNA | - |
dc.subject.keywordAuthor | Z-RNA | - |
dc.identifier.url | https://kiss.kstudy.com/thesis/thesis-view.asp?key=3824152 | - |
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