Dual Inhibition of NOX2 and Receptor Tyrosine Kinase by BJ-1301 Enhances Anticancer Therapy Efficacy via Suppression of Autocrine-Stimulatory Factors in Lung Cancer
DC Field | Value | Language |
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dc.contributor.author | Gautam, Jaya | - |
dc.contributor.author | Ku, Jin-Mo | - |
dc.contributor.author | Regmi, Sushil Chandra | - |
dc.contributor.author | Jeong, Hyunyoung | - |
dc.contributor.author | Wang, Ying | - |
dc.contributor.author | Banskota, Suhrid | - |
dc.contributor.author | Park, Myo-Hyeon | - |
dc.contributor.author | Nam, Tae-Gyu | - |
dc.contributor.author | Jeong, Byeong-Seon | - |
dc.contributor.author | Kim, Jung-Ae | - |
dc.date.accessioned | 2021-06-22T13:41:36Z | - |
dc.date.available | 2021-06-22T13:41:36Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 1535-7163 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/8939 | - |
dc.description.abstract | NADPH oxidase-derived reactive oxygen species (ROS) potentiate receptor tyrosine kinase (RTK) signaling, resulting in enhanced angiogenesis and tumor growth. In this study, we report that BJ-1301, a hybrid of pyridinol and alpha-tocopherol, exerts anticancer effects by dual inhibition of NADPH oxidase and RTK activities in endothelial and lung cancer cells. BJ-1301 suppresses ROS production by blocking translocation of NADPH oxidase cytosolic subunits to the cell membrane, thereby inhibiting activation. The potency of RTK inhibition by BJ-1301 was lower than that of sunitinib (a multi-RTK inhibitor), but the inhibition of downstream signaling pathways (e.g., ROS generation) and subsequent biological changes (e.g., NOX2 induction) by BJ-1301 was superior. Consistently, BJ-1301 inhibited cisplatin-resistant lung cancer cell proliferation more than sunitinib did. In xenograft chick or mouse tumor models, BJ-1301 inhibited lung tumor growth, to an extent greater than that of sunitinib or cisplatin. Treatments with BJ-1301 induced regression of tumor growth, potentially due to downregulation of autocrine-stimulatory ligands for RTKs, such as TGFa and stem cell factor, in tumor tissues. Taken together, the current study demonstrates that BJ-1301 is a promising anticancer drug for the treatment of lung cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC CANCER RESEARCH | - |
dc.title | Dual Inhibition of NOX2 and Receptor Tyrosine Kinase by BJ-1301 Enhances Anticancer Therapy Efficacy via Suppression of Autocrine-Stimulatory Factors in Lung Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Nam, Tae-Gyu | - |
dc.identifier.doi | 10.1158/1535-7163.MCT-16-0915 | - |
dc.identifier.scopusid | 2-s2.0-85030632173 | - |
dc.identifier.wosid | 000412220900009 | - |
dc.identifier.bibliographicCitation | MOLECULAR CANCER THERAPEUTICS, v.16, no.10, pp.2144 - 2156 | - |
dc.relation.isPartOf | MOLECULAR CANCER THERAPEUTICS | - |
dc.citation.title | MOLECULAR CANCER THERAPEUTICS | - |
dc.citation.volume | 16 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2144 | - |
dc.citation.endPage | 2156 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | NADPH OXIDASES | - |
dc.subject.keywordPlus | ALPHA-TOCOPHEROL | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | VITAMIN-E | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | KIT | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | BREAST | - |
dc.subject.keywordAuthor | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordAuthor | NADPH OXIDASES | - |
dc.subject.keywordAuthor | ALPHA-TOCOPHEROL | - |
dc.subject.keywordAuthor | HYDROGEN-PEROXIDE | - |
dc.subject.keywordAuthor | EPITHELIAL-CELLS | - |
dc.subject.keywordAuthor | VITAMIN-E | - |
dc.subject.keywordAuthor | ANGIOGENESIS | - |
dc.subject.keywordAuthor | KIT | - |
dc.subject.keywordAuthor | METAANALYSIS | - |
dc.subject.keywordAuthor | TOCOTRIENOL | - |
dc.identifier.url | https://mct.aacrjournals.org/content/16/10/2144 | - |
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