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Ceria-Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment
- Authors
- Soh, Min; Kang, Dong-Wan; Jeong, Han-Gil; Kim, Dokyoon; Kim, Do Yeon; Yang, Wookjin; Song, Changyeong; Baik, Seungmin; Choi, In-Young; Ki, Seul-Ki; Kwon, Hyek Jin; Kim, Taeho; Kim, Chi Kyung; Lee, Seung-Hoon; Hyeon, Taeghwan
- Issue Date
- Sep-2017
- Publisher
- John Wiley & Sons Ltd.
- Keywords
- ceria-zirconia nanoparticles; inflammation; reactive oxygen species; sepsis; therapeutic nanomedicine
- Citation
- Angewandte Chemie - International Edition, v.56, no.38, pp.11399 - 11403
- Indexed
- SCIE
SCOPUS
- Journal Title
- Angewandte Chemie - International Edition
- Volume
- 56
- Number
- 38
- Start Page
- 11399
- End Page
- 11403
- ISSN
- 1433-7851
- Abstract
- The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for removing O-2(-) and COH that are associated with inflammatory response and cell death. The synthesis is reported of 2 nm ceria-zirconia nanoparticles (CZ NPs) that possess a higher Ce3+/Ce4+ ratio and faster conversion from Ce4+ to Ce3+ than those exhibited by ceria nanoparticles. The obtained Ce0.7Zr0.3O2 (7CZ) NPs greatly improve ROS scavenging performance, thus regulating inflammatory cells in a very low dose. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two representative sepsis models. These findings suggest that 7CZ NPs have the potential as a therapeutic nanomedicine for treating ROS-related inflammatory diseases.
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Related Researcher
- Kim, DoKyoon
- ERICA 첨단융합대학 (ERICA 바이오나노공학전공)