Activity of LCB01-0371, a Novel Oxazolidinone, against Mycobacterium abscessus
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae Sung | - |
dc.contributor.author | Choe, Jin Ho | - |
dc.contributor.author | Kim, Young Jae | - |
dc.contributor.author | Yang, Chul-Su | - |
dc.contributor.author | Kwon, Hyun-Jin | - |
dc.contributor.author | Jeong, Jinsun | - |
dc.contributor.author | Kim, Guehye | - |
dc.contributor.author | Park, Da Eun | - |
dc.contributor.author | Jo, Eun-Kyeong | - |
dc.contributor.author | Cho, Young-Lag | - |
dc.contributor.author | Jang, Jichan | - |
dc.date.accessioned | 2021-06-22T13:42:56Z | - |
dc.date.available | 2021-06-22T13:42:56Z | - |
dc.date.issued | 2017-09 | - |
dc.identifier.issn | 0066-4804 | - |
dc.identifier.issn | 1098-6596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/9023 | - |
dc.description.abstract | Mycobacterium abscessus is a highly pathogenic drug-resistant rapidly growing mycobacterium. In this study, we evaluated the in vitro, intracellular, and in vivo activities of LCB01-0371, a novel and safe oxazolidinone derivative, for the treatment of M. abscessus infection and compared its resistance to that of other oxazolidinone drugs. LCB01-0371 was effective against several M. abscessus strains in vitro and in a macrophage model of infection. In the murine model, a similar efficacy to linezolid was achieved, especially in the lungs. We induced laboratory-generated resistance to LCB01-0371; sequencing analysis revealed mutations in rplC of T424C and G419A and a nucleotide insertion at the 503 position. Furthermore, LCB01-0371 inhibited the growth of amikacin-, cefoxitin-, and clarithromycin-resistant strains. Collectively, our data indicate that LCB01-0371 might represent a promising new class of oxazolidinones with improved safety, which may replace linezolid for the treatment of M. abscessus. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | American Society for Microbiology | - |
dc.title | Activity of LCB01-0371, a Novel Oxazolidinone, against Mycobacterium abscessus | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1128/AAC.02752-16 | - |
dc.identifier.scopusid | 2-s2.0-85028302625 | - |
dc.identifier.wosid | 000408309000091 | - |
dc.identifier.bibliographicCitation | Antimicrobial Agents and Chemotherapy, v.61, no.9, pp 1 - 12 | - |
dc.citation.title | Antimicrobial Agents and Chemotherapy | - |
dc.citation.volume | 61 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 12 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | MURINE MODEL | - |
dc.subject.keywordPlus | TUBERCULOSIS | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordAuthor | drug resistance | - |
dc.subject.keywordAuthor | LCB01-0371 | - |
dc.subject.keywordAuthor | Mycobacterium abscessus | - |
dc.subject.keywordAuthor | oxazolidinone | - |
dc.identifier.url | https://journals.asm.org/doi/10.1128/AAC.02752-16 | - |
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