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Sustainable Nanosheet Antioxidants for Sepsis Therapy via Scavenging Intracellular Reactive Oxygen and Nitrogen Species

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dc.contributor.authorYim, DaBin-
dc.contributor.authorLee, Da-Eun-
dc.contributor.authorSo, Yoonhee-
dc.contributor.authorChoi, Chanhee-
dc.contributor.authorSon, Wooic-
dc.contributor.authorJang, Kiseok-
dc.contributor.authorYang, Chul-Su-
dc.contributor.authorKim, Jong-Ho-
dc.date.accessioned2021-06-22T06:00:25Z-
dc.date.available2021-06-22T06:00:25Z-
dc.date.issued2020-08-
dc.identifier.issn1936-0851-
dc.identifier.issn1936-086X-
dc.identifier.urihttps://scholarworks.bwise.kr/erica/handle/2021.sw.erica/932-
dc.description.abstractSepsis is an aberrant systemic inflammatory response mediated by excessive production of reactive oxygen species (ROS) and reactive nitrogen species RNS). Developing an efficient antioxidant therapy for sepsis via scavenging ROS and RNS remains a big challenge owing to the insufficient activity and sustainability of conventional antioxidants. Herein, biocompatible transition-metal dichalcogenide antioxidants with excellent scavenging activity and sustainability for H2O2, O-2(center dot-), OH center dot, and nitric oxide are developed for effective sepsis treatment. WS2, MoSe2, and WSe2 nanosheets exfoliated and functionalized with a biocompatible polymer effectively scavenge mitochondrial and intracellular ROS and RNS in inflammatory cells. Among the nanosheets, WS2 most efficiently suppresses the excessive secretion of inflammatory cytokines along with scavenging ROS and RNS without affecting the expression levels of the anti-inflammatory cytokine and ROS-producing enzymes. The WS2 nanosheets significantly improve the survival rate up to 90% for severely septic mice by reducing systemic inflammation. The pharmacokinetics suggests that the WS2 nanosheets can be excreted from mice 3 days after intravenous injection. This work demonstrates the potential of therapeutic nanosheet antioxidants for effective treatment of ROS and RNS-related diseases.-
dc.format.extent13-
dc.language영어-
dc.language.isoENG-
dc.publisherAmerican Chemical Society-
dc.titleSustainable Nanosheet Antioxidants for Sepsis Therapy via Scavenging Intracellular Reactive Oxygen and Nitrogen Species-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1021/acsnano.0c03807-
dc.identifier.scopusid2-s2.0-85090077408-
dc.identifier.wosid000566341000092-
dc.identifier.bibliographicCitationACS Nano, v.14, no.8, pp 10324 - 10336-
dc.citation.titleACS Nano-
dc.citation.volume14-
dc.citation.number8-
dc.citation.startPage10324-
dc.citation.endPage10336-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.subject.keywordPlusTRANSITION-METAL DICHALCOGENIDES-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusFREE-RADICALS-
dc.subject.keywordPlusMONOLAYER MOS2-
dc.subject.keywordPlusSEPTIC SHOCK-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusWS2-
dc.subject.keywordPlusPHOTOLUMINESCENCE-
dc.subject.keywordPlusDYSFUNCTION-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordAuthornanotherapy-
dc.subject.keywordAuthorreactive oxygen species-
dc.subject.keywordAuthorreactive nitrogen species-
dc.subject.keywordAuthorsepsis-
dc.subject.keywordAuthorTMD antioxidant-
dc.identifier.urlhttps://pubs.acs.org/doi/10.1021/acsnano.0c03807-
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COLLEGE OF ENGINEERING SCIENCES > DEPARTMENT OF MATERIALS SCIENCE AND CHEMICAL ENGINEERING > 1. Journal Articles
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY > ERICA 의약생명과학과 > 1. Journal Articles

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